Volume 69, Issue 3, Pages (February 2018)

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Volume 69, Issue 3, Pages 349-351 (February 2018) Guilty by Association: Mapping Out the Molecular Sociology of Droplet Compartments Simon Alberti Molecular Cell Volume 69, Issue 3, Pages 349-351 (February 2018) DOI: 10.1016/j.molcel.2018.01.020 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Using Proximity Labeling to Analyze the Protein-Protein Interaction Network of RNP Granules (A) Proximity labeling strategy to identify interactors. A bait protein is fused to an enzyme (APEX, BirA∗) that generates reactive derivatives of biotin. After labeling, the biotinylated proteins are isolated and identified by mass spectrometry. (B–E) Use of proximity labeling to better understand different aspects of RNP granules, such as the formation of different types of RNP granules (B), RNP granule formation under different conditions (C) or in different cell types (D), or RNP granule differences between healthy and sick cells (E). Molecular Cell 2018 69, 349-351DOI: (10.1016/j.molcel.2018.01.020) Copyright © 2018 Elsevier Inc. Terms and Conditions