Stress Response, Tachykinin, and Cutaneous Inflammation

Slides:

Advertisements

Similar presentations

Glucocorticoids Augment the Chemically Induced Production and Gene Expression of Interleukin-1α through NF-κB and AP-1 Activation in Murine Epidermal.

Advertisements

Peptide Immunization Indicates that CD8+ T Cells are the Dominant Effector Cells in Trinitrophenyl-Specific Contact Hypersensitivity Stefan Martin, Michael.

Differential Regulation by IL-1β and EGF of Expression of Three Different Hyaluronan Synthases in Oral Mucosal Epithelial Cells and Fibroblasts and Dermal.

Immunologic Characterization of HIV-Specific DNA Vaccine

Photobiologic and Photoimmunologic Characteristics of XPA Gene-Deficient Mice Takeshi Horio, Hiroko Miyauchi-Hashimoto, Kazue Kuwamoto, Satoshi Horiki,

Volume 71, Issue 6, Pages (March 2007)

IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production Risa Tamagawa-Mineoka, Tsunao.

Juan Liu, Erin Harberts, Antonella Tammaro, Nicholas Girardi, Renata B

Cytokine Effects Induced by the Human Autoallergen α-NAC

Oxidation of Cell Surface Thiol Groups by Contact Sensitizers Triggers the Maturation of Dendritic Cells Saori Kagatani, Yoshinori Sasaki, Morihiko Hirota,

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes Marcel B.M. Teunissen, Jan.

Antigen-Specific Peripheral Tolerance Induced by Topical Application of NF-κB Decoy Oligodeoxynucleotide Iwao Isomura, Kunio Tsujimura, Akimichi Morita

Streptococcus Induces Circulating CLA+ Memory T-Cell-Dependent Epidermal Cell Activation in Psoriasis Marta Ferran, Ana B. Galván, Catalina Rincón, Ester.

Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis–Like Clinical Symptoms in NC/Nga Mice Gun-Dong Kim, Yong Seek Park, Hyun-Jong.

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis Erin G. Harper, Changsheng Guo,

IL-31 Receptor Alpha Expression in Epidermal Keratinocytes Is Modulated by Cell Differentiation and Interferon Gamma Ruth Heise, Mark M. Neis, Yvonne.

Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A Satoshi Matsukura, MD, Fumio Kokubu,

Keratinocyte Growth Inhibition by High-Dose Epidermal Growth Factor Is Mediated by Transforming Growth Factor β Autoinduction: A Negative Feedback Mechanism.

Abrogation of High-Affinity IgE Receptor-Mediated Mast Cell Activation at the Effector Phase Prevents Contact Hypersensitivity to Oxazolone Maiko Kobayashi,

Capsiate Inhibits DNFB-Induced Atopic Dermatitis in NC/Nga Mice through Mast Cell and CD4+ T-Cell Inactivation Ji H. Lee, Yun S. Lee, Eun-Jung Lee, Ji.

Targeting Effector Memory T Cells with the Small Molecule Kv1

Urupongsa Ausaneya, Akira Kawada, Yoshinori Aragane

Cutaneous T-Cell Lymphoma: The Yin and Yang of Inflammation and Neoplasia Xuesong Wu, Sam T. Hwang Journal of Investigative Dermatology Symposium Proceedings

CpG Oligodeoxynucleotides Prevent the Development of Scleroderma-Like Syndrome in Tight-Skin Mice by Stimulating a Th1 Immune Response Yan Shen, Motohide.

Activation of the Arylhydrocarbon Receptor Causes Immunosuppression Primarily by Modulating Dendritic Cells Anika Bruhs, Thomas Haarmann-Stemmann, Katrin.

Gangliosides GD1b, GT1b, and GQ1b Suppress the Growth of Human Melanoma by Inhibiting Interleukin-8 Production: the Inhibition of Adenylate Cyclase1

Exacerbated and Prolonged Allergic and Non-Allergic Inflammatory Cutaneous Reaction in Mice with Targeted Interleukin-18 Expression in the Skin Yusuke.

Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity Hideki Watanabe, Olivier Gaide, Virginie Pétrilli, Fabio Martinon,

Anne T. Funding, Claus Johansen, Matthias Gaestel, Bo M

Topical Imiquimod Treatment Prevents UV-Light Induced Loss of Contact Hypersensitivity and Immune Tolerance Thomas H. Thatcher, Irina Luzina, Rita Fishelevich,

Abrogation of High-Affinity IgE Receptor-Mediated Mast Cell Activation at the Effector Phase Prevents Contact Hypersensitivity to Oxazolone Maiko Kobayashi,

Impaired Initiation of Contact Hypersensitivity by FTY720

All-Trans-Retinoic Acid Induces Interleukin-8 via the Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase Pathways in Normal Human Keratinocytes

Tsugunoubu Andoh, Yuichi Yageta, Hiroshi Takeshima, Yasushi Kuraishi

Shelley Gorman, Melinda A. Judge, Prue H. Hart

Eicosapentaenoic Acid, a n-3 Polyunsaturated Fatty Acid Differentially Modulates TNF- α, IL-1α, IL-6 and PGE2 Expression in UVB-Irradiated Human Keratinocytes

Production and Pharmacologic Modulation of the Granulocyte-Associated Allergic Responses to Ovalbumin in Murine Skin Models Induced by Injecting Ovalbumin-

The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells Juha Punnonen, MD, PhD, Hans Yssel, PhD,

Contact Hypersensitivity in MHC Class II-Deficient Mice Depends on CD8 T Lymphocytes Primed by Immunostimulating Langerhans Cells Anne Bouloc, Andrea.

Afferent and Efferent Phases of Allergic Contact Dermatitis (ACD) Can Be Induced After a Single Skin Contact with Haptens: Evidence Using a Mouse Model.

Fetal Calf Serum-Free Generation of Functionally Active Murine Dendritic Cells Suitable for In Vivo Therapeutic Approaches Gabriele Müller, Anke Müller,

UVB and Proinflammatory Cytokines Synergistically Activate TNF-α Production in Keratinocytes through Enhanced Gene Transcription Muhammad M. Bashir,

Human Keratinocytes Respond to Osmotic Stress by p38 Map Kinase Regulated Induction of HSP70 and HSP27 M. Garmyn, A. Pupe Journal of Investigative Dermatology

Timothy J. Paradis, Susan H. Cole, Robin T. Nelson, Ronald P. Gladue

Cyclooxygenase-2 Inhibition Promotes Enhancement of Antitumor Responses by Transcutaneous Vaccination with Cytosine-Phosphate-Guanosine- Oligodeoxynucleotides.

Aloe Barbadensis Extracts Reduce the Production of Interleukin-10 After Exposure to Ultraviolet Radiation Son Won Byeon Journal of Investigative Dermatology

Hirotake Suzuki, Binghe Wang, Gulnar M

Characterization of the Sensitizing Potential of Chemicals by In Vitro Analysis of Dendritic Cell Activation and Skin Penetration Pierre Aeby, Christoph.

Decreased Prostaglandin E2 Production by Inflammatory Cytokine and Lower Expression of EP2 Receptor Result in Increased Collagen Synthesis in Keloid.

IL-12 affects Dermatophagoides farinae–induced IL-4 production by T cells from pediatric patients with mite-sensitive asthma Takeshi Noma, MD, PhD, Izumi.

The Effect of Thioredoxin on the Expression of Proopiomelanocortin-Derived Peptides, the Melanocortin 1 Receptor and Cell Survival of Normal Human Keratinocytes

Double-Stranded RNA-Exposed Human Keratinocytes Promote Th1 Responses by Inducing a Type-1 Polarized Phenotype in Dendritic Cells: Role of Keratinocyte-Derived.

Augmentation of UVB Radiation-Mediated Early Gene Expression by the Epidermal Platelet-Activating Factor Receptor Jeffrey B. Travers, Howard J. Edenberg,

UVA-Induced Immune Suppression Through an Oxidative Pathway

Repeated Topical Challenge with Chemical Antigen Elicits Sustained Dermatitis in NC/Nga Mice in Specific-Pathogen-Free Condition Yoshiaki Tomimori, Yoshitaka.

IL-23 Antagonizes UVR-Induced Immunosuppression through Two Mechanisms: Reduction of UVR-Induced DNA Damage and Inhibition of UVR-Induced Regulatory T.

Interleukin-21 Inhibits Dendritic Cell-Mediated T Cell Activation and Induction of Contact Hypersensitivity In Vivo Donald C. Foster, Ralf Paus Journal.

Cutaneous Hypersensitivities to Hapten Are Controlled by IFN-γ-Upregulated Keratinocyte Th1 Chemokines and IFN-γ-Downregulated Langerhans Cell Th2 Chemokines

Blazej Zbytek, Andrzej T. Slominski

Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Shigeki Inui, Yoko Fukuzato,

Human Epidermal Langerhans Cells Express the Immunoregulatory Enzyme Indoleamine 2,3-Dioxygenase Dagmar von Bubnoff, Huguette Bausinger, Heike Matz,

Ultraviolet B Radiation Upregulates the Production of Macrophage Migration Inhibitory Factor (MIF) in Human Epidermal Keratinocytes Tadamichi Shimizu,

CpG Immunostimulatory Sequences Enhance Contact Hypersensitivity Responses in Mice Hitoshi Akiba, Masataka Satoh, Keiji Iwatsuki, Dominique Kaiserlian,

Akane Tanaka, Susumu Muto, Kyungsook Jung, Akiko Itai, Hiroshi Matsuda

Skin-Infiltrating Monocytes/Macrophages Migrate to Draining Lymph Nodes and Produce IL-10 After Contact Sensitizer Exposure to UV-Irradiated Skin Eiko.

Patrizia Stoitzner, Christoph H

Skin Contact Irritation Conditions the Development and Severity of Allergic Contact Dermatitis Marlene Bonneville, Cyril Chavagnac, Marc Vocanson, Aurore.

Hyun Jeong Park, Hee Jung Kim, Jun Young Lee, Baik Kee Cho, Richard L

Hapten-Specific Tolerance Promoted by Calcitonin Gene-Related Peptide

Epicutaneous Sensitization with Protein Antigen Induces Th9 Cells

Presentation transcript:

Stress Response, Tachykinin, and Cutaneous Inflammation Ichiro Katayama, Sang-Jae Bae, Yo-ichiro Hamasaki Journal of Investigative Dermatology Symposium Proceedings Volume 6, Issue 1, Pages 81-86 (November 2001) DOI: 10.1046/j.0022-202x.2001.00015.x Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Experimental protocol. BALB/C mice received nine epicutaneous applications of 0.1% diflucotolone on alternate days on the flank skin. After seven applications, each mouse was sensitized with DNFB, TNCB. or oxazolone. Twenty-four hours after the last applications of 0.1% diflucotolone, each mouse was challenged with corresponding hapten on the right pinna skin. The left pinna was used as vehicle control. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Augmentation of contact sensitivity skin reaction by GC.Igawa et al (1997). 0.1% diflucotolone valerate was applied on the flank skin nine times on alternate days (seven applications before and two applications after sensitization). Mice were sensitized with 0.5% DNFB on day 12 (seventh application of diflucotolone valerate) on the same site of flank skin that mice received 0.1% diflucotolone seven times, and then skin was tested on the right pinna on day 17 (one day after the nine applications of diflucotolone valerate). (A) Dose response of diflucotolone valerate on DNFB contact sensitivity reaction; (B) effect of a different kind of GC on DNFB contact sensitivity reaction. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Augmentation of IgE anti-DNP antibody induced passive cutaneous anaphylaxis elicited on the pinna by long-term topical GC applied on distant flank skin. Fifty microliters of 0.1% diflucortolone valerate or 1α-24 (OH)2 D3 (0.05 µg per ml) in ethanol were applied on the flank skin seven times on alternate days. Mice then received intravenous application of monoclonal IgE anti-DNP antibody 1h after the last application (final PCA titer > ×2560). One hour after injection, mice were challenged with 0.15% DNFB in acetone:olive oil (4:1) on the right pinna. The left pinna was painted with vehicle as a control. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Effect of hydrocortisone on IL1α production by Pam 212 cells through NFĸB activation.Miyazaki et al (2000). (A) Various concentrations of hydrocortisone were added to the culture medium of Pam 212 KC cell lines and IL1α concentration was measured by ELISA 24h after stimulation. (B) Effect of PDTC on TNBS and hydrocortisone-induced NFĸB expression and IL1α production by Pam 212 cells. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Time course and concentration-dependent production of SP by cultured KC.Bae et al (1999). Normal human KC were cultured in KGM CC-3111 medium (complete medium) supplemented with BPE, hEGF, insulin, antibiotics, and hydrocortisone as described above. At the semiconfluent stage, the cells were washed with ice-chilled DMEM and replaced with KGM medium without hydocortisone, for 24h. At the start of the experiment, the medium was replaced with fresh KGM medium containing variously diluted SP and then culture supernatants were collected at various times and donated for ELISA assay. (A) The dose–response effect of SP on autocrine production of SP in cultured normal human KC (NHK). (B) Time course of SP-induced SP production in cultured normal human KC (NHK). Results are expressed as the means ± SD. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 6 SP gene expression in SP-stimulated normal KC.Bae et al (1999). To clarify the SP gene expression in normal KC, we performed RT-PCR and Southern blot analysis. For specificity of mRNA expression of PPT-A, we performed Southern blot analysis as described in the Materials and Methods. The values were determined by scanning densitometer and expressed in relation to actin scanning density. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 7 Stress-induced augmentation of cutaneous inflammation. Stress-induced GC or long-term topical GC and its withdrawal might induce epidermal cytokine and SP, resulting in augmented cutaneous inflammations. Th1-derived IFNγ or Th1/Th2-derived IL-3 might modulate these circuits. Journal of Investigative Dermatology Symposium Proceedings 2001 6, 81-86DOI: (10.1046/j.0022-202x.2001.00015.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions