Figure 1 Overview of the image acquisition and analysis steps.

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Figure 1 Overview of the image acquisition and analysis steps. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, Volume 142, Issue 5, 08 April 2019, Pages 1270–1281, https://doi.org/10.1093/brain/awz067 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 Correlation of perioperative regional brain growth rate with the 1-year Bayley-III Composite Language Score ... Figure 2 Correlation of perioperative regional brain growth rate with the 1-year Bayley-III Composite Language Score at 12 months of age. (A) Brain regions significantly (TFCE-corrected P ≤ 0.025) correlating with LCS are shown as red-to-yellow clusters overlaid on a T<sub>2</sub>-weighted MRI template, blue outline (within the red overlay): significant cluster after adjusting for length of hospital stay. (B) The correlation coefficient map (thresholded at R ≥ 0.25). (C) Correlation plot. ACM = two patients with middle cerebral artery stroke; ACP = one patient with posterior cerebral artery stroke; IVH = one patient with intraventricular haemorrhage reported on the preoperative MRI; PMCC = Pearson’s product-moment correlation coefficient. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, Volume 142, Issue 5, 08 April 2019, Pages 1270–1281, https://doi.org/10.1093/brain/awz067 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 Comparison of brain growth rate correlating with the 1-year Bayley-III cognitive, motor and language scores. ... Figure 3 Comparison of brain growth rate correlating with the 1-year Bayley-III cognitive, motor and language scores. Brain regions with moderate to strong (R ≥ 0.25) positive correlation appear as a colour-coded overlay fused with the MRI template. PMCC = Pearson’s product-moment correlation coefficient. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, Volume 142, Issue 5, 08 April 2019, Pages 1270–1281, https://doi.org/10.1093/brain/awz067 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Effect of length of hospital stay on regional brain growth rate, corrected for LCS, SES, gender and MRI ... Figure 4 Effect of length of hospital stay on regional brain growth rate, corrected for LCS, SES, gender and MRI software version. (A) Test statistic maps (t), positive values referring to positive correlation between regional growth rate and hospitalization duration. (B) Brain regions with significant (TFCE-corrected P ≤ 0.025) positive correlation are depicted as red-to-yellow overlays, and were fused with the MRI template. The brain region in which brain growth rate correlated with LCS is displayed as white outlines. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, Volume 142, Issue 5, 08 April 2019, Pages 1270–1281, https://doi.org/10.1093/brain/awz067 The content of this slide may be subject to copyright: please see the slide notes for details.