From Benchtop to Bedside From benchtop to bedside  this is a very hot phrase right now in medicine, but what does it mean? We’ll find out over the next hour… Implantable Medical Devices

The heart. And that’s what this guys wants…but why The heart! And that’s what this guys wants…but why? Why is it so important to him to have a heart? Answers: 1) It will make him happy (and other emotions) 2) He needs it to live! Blood circulation  oxygen, CO2 and many hormones! But how does the heart do it all???

Because it’s the pump for the body Because it’s the pump for the body! It circulates blood through muscular contractions, often referred to as heart beats. Does anyone know the pathway of blood if we’re starting here in the left ventricle? LV  Aorta  Systemic Circulation  Vena Cava  Right Atrium  RV  Pulmonary Circulation  Left Atrium  LV So how much blood does the average adult human have in their circulation?  5 L But, just like any pump, it can end up failing…

Advanced Heart Failure Stage IV – Severe. If any physical activity is undertaken, discomfort increases. Causes include artery disease, heart attack, high blood pressure, and cardiomyopathy The left ventricle often fails first…why? Leads to inadequate pumping of oxygenated blood throughout the body

So what do we do for someone with a heart that is injured? So what do we do for someone who’s heart is not working properly?

Mechanical Circulatory Support!

What is this? HeartWare Centrifugal LVAD Inserts into the left ventricle and acts as a detour for the blood! It draws blood from the ventricle through the spinning of a rotor in the cylindrical casing, and propels it back to the aorta

Who is involved? Engineers Cardiovascular Surgeons

Professional Collaboration Engineers work with Doctors and Doctors work with Engineers Learn from one another to develop solutions

3 Concerns of Implantable Devices Size – the smaller the better! Cost – price efficiency is key! Biocompatibility and Safety – must be accepted by the host and not cause complications!

Who is involved? Engineers Cardiovascular Surgeons

Cardiovascular Surgeons Learn the cardiovascular anatomy of your patient and identify the problem. Discuss with your engineering colleagues about possible solutions to the problem. After those discussions conclude, begin the surgical procedure to establish the systemic circulation loop (ignore the right chambers of the heart). Meet with the engineering team to learn about the device and how it is intended to treat the problem

Purse-String Suture Technique

Biomedical Engineers Determine which engineer will specialize in Electrical Engineering and which will specialize in Mechanical Engineering Meet with the surgical team and learn more about the problem they are facing. Work with your partner to develop a solution to the problem, keeping the 3 key points of implantable devices in mind. Develop instructions for the surgical team to follow during implementation.

Circuitry and Design

CARDIOVASCULAR SURGEONS Learn Anatomy and Identify the Problem Begin the Surgical Procedure Meet and Discuss the Problem Implement the Device POINTS (0-10 for each) Biocompatibility - Neat/compact? Is there a lot of extra glue? Effectiveness - Does it WORK!? Marketability - Creative name! Determine Role Specialization Record the time you are done the surgery. The team with the least amount of leaking wins! If we have a tie, it will go to the team that completed surgery first. Design the Device BIOMEDICAL ENGINEERS