Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology?

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Presentation transcript:

Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology? Greene Donald Royster, M.D., Kavitha Krishnamoorthy, M.D., John M. Csokmay, M.D., Belinda J. Yauger, M.D., Rebecca J. Chason, M.D., Alan H. DeCherney, M.D., Erin F. Wolff, M.D., Micah J. Hill, D.O. Fertility and Sterility Volume 106, Issue 2, Pages 363-370.e3 (August 2016) DOI: 10.1016/j.fertnstert.2016.04.023 Copyright © 2016 Terms and Conditions

Figure 1 Greater than efficiency curves evaluating the effect of estradiol (E2) on adverse placental outcomes. The occurrence of adverse outcomes was calculated for each E2 threshold in increments of 500 pg/mL. (A) All cycles in the study. (B) All cycles in the study broken down into intracytoplasmic sperm injection (ICSI) versus IVF. Fertility and Sterility 2016 106, 363-370.e3DOI: (10.1016/j.fertnstert.2016.04.023) Copyright © 2016 Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curves evaluating the ability of peak E2 measurements to predict adverse placental outcomes in (A) all adverse outcomes, (B) hypertensive disorders, and (C) growth disorders. Fertility and Sterility 2016 106, 363-370.e3DOI: (10.1016/j.fertnstert.2016.04.023) Copyright © 2016 Terms and Conditions

Supplemental Figure 1 Greater than efficiency curves evaluating the effect of estradiol (E2) on adverse placental outcomes. The occurrence of various adverse outcomes was calculated for each E2 threshold in increments of 500 pg/mL. Fertility and Sterility 2016 106, 363-370.e3DOI: (10.1016/j.fertnstert.2016.04.023) Copyright © 2016 Terms and Conditions

Supplemental Figure 2 Greater than efficiency curves evaluating the effect of estradiol (E2) on adverse placental outcomes in patients undergoing intracytoplasmic sperm injection (ICSI) without male factor infertility (−MF) and with male factor infertility (+MF). The occurrence of adverse outcomes was calculated for each E2 threshold in increments of 500 pg/mL. Fertility and Sterility 2016 106, 363-370.e3DOI: (10.1016/j.fertnstert.2016.04.023) Copyright © 2016 Terms and Conditions