More Is Less: IL-9 in the Resolution of Inflammation

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More Is Less: IL-9 in the Resolution of Inflammation Fotios Karagiannis, Christoph Wilhelm Immunity Volume 47, Issue 3, Pages 403-405 (September 2017) DOI: 10.1016/j.immuni.2017.09.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Function of IL-9 in the Resolution of Joint Inflammation in RA Rauber et al. (2017) found that autocrine IL-9 expands the ILC2 pool and upregulates the expression of ICOS ligand (ICOSL) and GITR ligand (GITRL) on ILC2s. Increased expression of these ligands boosts the suppressive capacity of Treg cells to suppress Th17-mediated joint inflammation, resulting in the resolution of inflammation. Immunity 2017 47, 403-405DOI: (10.1016/j.immuni.2017.09.004) Copyright © 2017 Elsevier Inc. Terms and Conditions