Volume 153, Issue 6, Pages (December 2017)

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Volume 153, Issue 6, Pages 1475-1478 (December 2017) Human Intestinal Microbiota and Colorectal Cancer: Moving Beyond Associative Studies Christian Jobin Gastroenterology Volume 153, Issue 6, Pages 1475-1478 (December 2017) DOI: 10.1053/j.gastro.2017.10.030 Copyright © 2017 Terms and Conditions

Figure 1 Colorectal cancer (CRC) biota promotes neoplastic lesions after oral transfer into mice. Introduction of stools from CRC patients into either axozymethane (AOM)-exposed or germ-free mice promotes the development of intestinal polyps or proliferative response respectively. Microbial composition present in the stools of mice reveals increased relative abundance of bacterial species forming networks in CRC patients. Colonic tissues from CRC biota associated mice showed increased immune cell recruitment, as well as immune and oncogenic gene expression. Gastroenterology 2017 153, 1475-1478DOI: (10.1053/j.gastro.2017.10.030) Copyright © 2017 Terms and Conditions