Dynamic QT Interval Changes from Supine to Standing in Healthy Children Audrey Dionne, MD, Anne Fournier, MD, Nagib Dahdah, MD, Dominic Abrams, MD, Paul.

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Dynamic QT Interval Changes from Supine to Standing in Healthy Children Audrey Dionne, MD, Anne Fournier, MD, Nagib Dahdah, MD, Dominic Abrams, MD, Paul Khairy, MD, PhD, Sylvia Abadir, MD Canadian Journal of Cardiology Volume 34, Issue 1, Pages 66-72 (January 2018) DOI: 10.1016/j.cjca.2017.10.016 Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 1 QT and corrected QT (QTc) changes on standing. Example of QT interval and corrected QT (QTc using Bazett formula) changes during the standing test in a patient with no change in QT interval on standing but an increase in QTc resulting from an increase in heart rate. (A) Baseline. (B) On standing at maximal tachycardia. (C) Five minutes into recovery. Canadian Journal of Cardiology 2018 34, 66-72DOI: (10.1016/j.cjca.2017.10.016) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 2 QT and corrected QT (QTc) changes on standing. Changes in QT interval and QTc measurements during the standing test from baseline to recovery. HR, heart rate. Canadian Journal of Cardiology 2018 34, 66-72DOI: (10.1016/j.cjca.2017.10.016) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 3 Corrected QT (QTc) changes on standing according to heart rate. (A) QTc changes on standing according to the heart rate response and (B) baseline QTc. (A) The magnitude of QTc change (Δ QTc) was positively correlated with heart rate increase, meaning that a patient with an important heart rate increase exhibited a greater change in QTc on standing. (B) The Δ QTc had a weak negative correlation with baseline QTc, meaning that a patient with a higher baseline QTc had less increase in QTc on standing. Canadian Journal of Cardiology 2018 34, 66-72DOI: (10.1016/j.cjca.2017.10.016) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions

Figure 4 QT and corrected QT (QTc) changes on standing comparing patients with LQTS and healthy controls. (A) QT change measurements during the standing test from baseline to recovery. (B) QTc change measurements during the standing test from baseline to recovery. HR, heart rate. Canadian Journal of Cardiology 2018 34, 66-72DOI: (10.1016/j.cjca.2017.10.016) Copyright © 2017 Canadian Cardiovascular Society Terms and Conditions