Volume 15, Issue 4, Pages (December 2008)

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Volume 15, Issue 4, Pages 233-242 (December 2008) Prehepatic portal hypertension worsens the enterohepatic redox balance in thioacetamide-cirrhotic rats M.A. Aller, E. Vara, C. García, M. Méndez, M. Méndez-López, I. Mejía, L. López, J.L. Arias, J. Arias Pathophysiology Volume 15, Issue 4, Pages 233-242 (December 2008) DOI: 10.1016/j.pathophys.2008.09.003 Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Figure 1 Schematic representation of the splanchnic alterations related with prehepatic portal hypertension associated with thioacetamide administration in the rat. Triple partial portal vein ligation (a) plus cirrhosis by thioacetamide (b) induce mesenteric venous vasculopathy (c), splenomegaly (d), portosystemic collateral circulation (e) and mesenteric lymphadenopathy (f). Pathophysiology 2008 15, 233-242DOI: (10.1016/j.pathophys.2008.09.003) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Figure 2 Malondialdehyde (MDA) and catalase (CAT) liver and ileum levels in control rats, in portal hypertensive rats by triple partial portal vein ligation (TPVL), in thioacetamide-administered rats (TAA) and in rats with TPVL plus TAA. **p<0.01, ***p<0.001: statistically significant value in relation with control rats. °p<0.05: statistically significant value in relation with TAA-rats. Pathophysiology 2008 15, 233-242DOI: (10.1016/j.pathophys.2008.09.003) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Figure 3 Cytosolic superoxide dismutase (cSOD) and mitochondrial superoxide dismutase (mSOD) liver and ileum concentrations in control rats, in portal hypertensive rats by TPVL, in TAA and in rats with TPVL plus TAA. *p<0.05; **p<0.01, ***p<0.001: statistically significant value in relation with control rats. °p<0.05: statistically significant value in relation with TAA-rats. Pathophysiology 2008 15, 233-242DOI: (10.1016/j.pathophys.2008.09.003) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Figure 4 Glutathione transferase (GSH-t) and glutathione peroxidase (GSH-Px) liver and ileum concentrations in control rats, in portal hypertensive rats by TPVL, in TAA and in rats with TPVL plus TAA. **p<0.01, ***p<0.001: statistically significant value in relation with Control rats. °p<0.05; °°p<0.01: statistically significant value in relation with TAA-rats. Pathophysiology 2008 15, 233-242DOI: (10.1016/j.pathophys.2008.09.003) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions