Synthetic Biology Select   Cell  Volume 140, Issue 1, (January 2010) DOI: 10.1016/j.cell.2009.12.051 Copyright © 2010 Terms and Conditions

Overlay of the crystal structure of the rationally designed protein (cyan) with the structure predicted by computational modeling (yellow). Image courtesy of Y. Lu. Cell 2010 140, DOI: (10.1016/j.cell.2009.12.051) Copyright © 2010 Terms and Conditions

Tripartite fusion proteins in which a test protein is inserted into the antibiotic resistance gene TEM1-β-lactamase (β-lac) can be used to select for amino acid substitutions that improve protein stability. Figure courtesy of J. Bardwell. Cell 2010 140, DOI: (10.1016/j.cell.2009.12.051) Copyright © 2010 Terms and Conditions

A cryo-electron tomogram of Mycoplasma pneumoniae. Image courtesy of A A cryo-electron tomogram of Mycoplasma pneumoniae. Image courtesy of A.-C. Gavin. Cell 2010 140, DOI: (10.1016/j.cell.2009.12.051) Copyright © 2010 Terms and Conditions