Loss of Response to Vedolizumab and Ability of Dose Intensification to Restore Response in Patients With Crohn’s Disease or Ulcerative Colitis: A Systematic.

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Presentation transcript:

Loss of Response to Vedolizumab and Ability of Dose Intensification to Restore Response in Patients With Crohn’s Disease or Ulcerative Colitis: A Systematic Review and Meta-analysis Laurent Peyrin-Biroulet, Silvio Danese, Marjorie Argollo, Lieven Pouillon, Spyros Peppas, Marien Gonzalez-Lorenzo, Theodore Lytras, Stefanos Bonovas Clinical Gastroenterology and Hepatology Volume 17, Issue 5, Pages 838-846.e2 (April 2019) DOI: 10.1016/j.cgh.2018.06.026 Copyright © 2019 AGA Institute Terms and Conditions

Figure 1 Summary of the evidence search and selection process (flow chart). Clinical Gastroenterology and Hepatology 2019 17, 838-846.e2DOI: (10.1016/j.cgh.2018.06.026) Copyright © 2019 AGA Institute Terms and Conditions

Figure 2 Forest plot of incidence rates of loss of response to vedolizumab maintenance therapy in Crohn’s disease. CI, confidence interval. Clinical Gastroenterology and Hepatology 2019 17, 838-846.e2DOI: (10.1016/j.cgh.2018.06.026) Copyright © 2019 AGA Institute Terms and Conditions

Figure 3 Forest plot of incidence rates of loss of response to vedolizumab maintenance therapy in ulcerative colitis. CI, confidence interval. Clinical Gastroenterology and Hepatology 2019 17, 838-846.e2DOI: (10.1016/j.cgh.2018.06.026) Copyright © 2019 AGA Institute Terms and Conditions

Figure 4 Forest plot of efficacy of vedolizumab intensification in secondary nonresponders with inflammatory bowel disease. CI, confidence interval. Clinical Gastroenterology and Hepatology 2019 17, 838-846.e2DOI: (10.1016/j.cgh.2018.06.026) Copyright © 2019 AGA Institute Terms and Conditions