NO Signals from the Cancer Stem Cell Niche

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Presentation transcript:

NO Signals from the Cancer Stem Cell Niche Joan Seoane Cell Stem Cell Volume 6, Issue 2, Pages 97-98 (February 2010) DOI: 10.1016/j.stem.2010.01.007 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 NO Induces Stem Cell-like Characteristics in the Perivascular Niche Endothelial cells in PDGF-induced gliomas secrete NO that promotes stem cell-like characteristics in cells present in the perivascular niche through the activation of the cGMP/PKG pathway and Notch. Endothelial cells are represented in red, CSCs are represented in blue, and non-CSCs are represented in green. Cell Stem Cell 2010 6, 97-98DOI: (10.1016/j.stem.2010.01.007) Copyright © 2010 Elsevier Inc. Terms and Conditions