Adenovirus encoding soluble tumor necrosis factor α receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung Takashi.

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Presentation transcript:

Adenovirus encoding soluble tumor necrosis factor α receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung Takashi Suda, MD, Tsutomu Tagawa, MD, Samer A Kanaan, MD, Benjamin D Kozower, MD, Niccolò Daddi, MD, T Mohanakumar, PhD, G.Alexander Patterson, MD, FRCS(C) The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 4, Pages 1155-1161 (October 2003) DOI: 10.1016/S0022-5223(03)00939-5

Figure 1 Immunohistochemistry for β-gal (blue) and sTNF-RI-Ig (brown) gene expression in rat lungs. Strong positive staining was observed in airway epithelial cells in cotransfected lungs. (A, original magnification, 100×; B, original magnification 400×.) The nontransfected control specimen is shown in C at 100× magnification. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1155-1161DOI: (10.1016/S0022-5223(03)00939-5)

Figure 2 Mean β-gal protein expression on days 2 and 7 was not significantly different between the cotransfection (sTNF-RI-Ig and β-gal) and β-gal groups. In the β-gal group β-gal protein expression was evident on day 2, decreased at day 14, and undetectable on day 56. β-Gal expression in the cotransfection group was prolonged and significantly higher for days 14 to 56 versus that in the β-gal group. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1155-1161DOI: (10.1016/S0022-5223(03)00939-5)

Figure 3 Antiadenovirus antibody production in the cotransfection group was significantly higher than that in the β-gal group. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1155-1161DOI: (10.1016/S0022-5223(03)00939-5)