Benjamin A. Rybicki, Robert C. Elston

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Presentation transcript:

The Relationship between the Sibling Recurrence-Risk Ratio and Genotype Relative Risk Benjamin A. Rybicki, Robert C. Elston The American Journal of Human Genetics Volume 66, Issue 2, Pages 593-604 (February 2000) DOI: 10.1086/302778 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 A, Relationship between λS and γ for disease-susceptibility allele frequencies of .01–.5 under a single-locus dominant-inheritance model. B, Relationship between λS and γ for disease-susceptibility-allele frequencies of .01–.5 under a single-locus recessive-inheritance model. The American Journal of Human Genetics 2000 66, 593-604DOI: (10.1086/302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 1), in which at least one disease-susceptibility allele from each locus must be present for increased disease risk. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 2), in which two copies of a disease-susceptibility allele from each locus must be present for increased disease risk. C, Relationship between λS and γ, for disease-susceptibility allele frequencies of .01–.5, under a two-locus epistatic-inheritance model (epistatic model 3), in which a total of three or more copies of a disease-susceptibility allele from both loci must be present for increased disease risk. The American Journal of Human Genetics 2000 66, 593-604DOI: (10.1086/302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus dominant-additive-inheritance model. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus recessive-additive-inheritance model. The American Journal of Human Genetics 2000 66, 593-604DOI: (10.1086/302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 4 A, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus dominant-multiplicative -inheritance model. B, Relationship between λS and γ, for disease-susceptibility-allele frequencies of .01–.5, under a two-locus recessive-multiplicative-inheritance model. The American Journal of Human Genetics 2000 66, 593-604DOI: (10.1086/302778) Copyright © 2000 The American Society of Human Genetics Terms and Conditions