Volume 11, Issue 3, Pages (March 2014)

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Volume 11, Issue 3, Pages 360-366 (March 2014) Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: Intermediate and long-term follow-up Marmar Vaseghi, MD, MS, Jean Gima, RN, MSN, NP, Christopher Kanaan, BS, Olujimi A. Ajijola, MD, PhD, Alexander Marmureanu, MD, Aman Mahajan, MD, PhD, Kalyanam Shivkumar, MD, PhD, FHRS Heart Rhythm Volume 11, Issue 3, Pages 360-366 (March 2014) DOI: 10.1016/j.hrthm.2013.11.028 Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 1 Flow chart of the study cohort. Of the 41 patients, 27 underwent bilateral and 14 underwent left cardiac sympathetic denervation (CSD). LTF = patients lost to long-term follow-up (F/U) with regard to implantable cardioverter-defibrillator (ICD) shock status. Heart Rhythm 2014 11, 360-366DOI: (10.1016/j.hrthm.2013.11.028) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 2 Top: Freedom from implantable cardioverter-defibrillator (ICD) shock. Kaplan-Meier curve for freedom from ICD shock only is shown. For this analysis, death was censored and the patients who were lost to long-term follow were censored at the last follow-up, which was approximately 2 weeks post-procedure. Bottom: Survival free from ICD shock. Kaplan-Meier curves for survival free from ICD shock as well as risk of death and shock for this cohort are shown. Because of the higher incidence of death in this cohort, the survival free from ICD shocks was also driven by the high risk of mortality in this patient population. Heart Rhythm 2014 11, 360-366DOI: (10.1016/j.hrthm.2013.11.028) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 3 Analysis of shock-free survival in the bilateral vs left cardiac sympathetic denervation (CSD) groups. Kaplan-Meier curves for survival free from implantable cardioverter-defibrillator (ICD) shocks are shown for both the bilateral and left CSD subgroups. The 50% median time to shock-free survival was 366 days in the bilateral CSD group and 128 days in the left CSD group (P = .04). The greater survival free of ICD shocks in the bilateral CSD group was partly driven by the higher mortality rate in the left CSD group. Heart Rhythm 2014 11, 360-366DOI: (10.1016/j.hrthm.2013.11.028) Copyright © 2014 Heart Rhythm Society Terms and Conditions

Figure 4 Burden of implantable cardioverter-defibrillator (ICD) shocks pre- and postprocedure. At mean follow-up, the total number of ICD shocks was significantly reduced in both the left and bilateral cardiac sympathetic denervation (CSD) groups after the CSD procedure compared to preprocedure (mean ± SD). Heart Rhythm 2014 11, 360-366DOI: (10.1016/j.hrthm.2013.11.028) Copyright © 2014 Heart Rhythm Society Terms and Conditions