Apoptosis-targeted therapies for cancer

Slides:

Advertisements

Similar presentations

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Advertisements

Cell Physiol Biochem 2017;42:2582– DOI: /

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP CHEST

Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration- resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo

The Kinase-Independent, Second Life of CDK6 in Transcription

Charles Swanton, Julian Downward Cancer Cell

Connecting COX-2 and Wnt in cancer

Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era Joon H. Uhm, MD, Alyx B. Porter,

Neuronal Differentiation

Volume 100, Issue 1, Pages (January 2000)

Warren S. Pear, M. Celeste Simon Cancer Cell

The Path(way) Less Traveled: A Pathway-Oriented Approach to Providing Information about Precision Cancer Medicine on My Cancer Genome Alexandria D. Taylor,

HER2/HER3 heterodimers in prostate cancer

Dan Gordon Gastroenterology Volume 114, Issue 4, (April 1998)

Pancreatic Cancer: Basic and Clinical Aspects

p53 and Apoptosis: It's Not Just in the Nucleus Anymore

Personalizing Therapy for Colorectal Cancer

The Ripoptosome: Death Decision in the Cytosol

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Making Sense of HDAC2 Mutations in Colon Cancer

Personalizing Therapy for Colorectal Cancer

Polycomb Regulates NF-κB Signaling in Cancer through miRNA

Regulating Cancer Stem Cells the miR Way

Volume 13, Issue 1, Pages 1-2 (January 2008)

A Radical Role for p38 MAPK in Tumor Initiation

Focus on multiple myeloma

The Case of the Disappearing Drug Target

Identification of TOR Signaling Complexes

A genome-based strategy uncovers frequent BRAF mutations in melanoma

Apoptosis, Up the Ante Cancer Cell

Apoptosis-targeted therapies for cancer

Keratinocyte Apoptosis in Epidermal Development and Disease

Taru Muranen, Funda Meric-Bernstam, Gordon B. Mills Cancer Cell

Volume 20, Issue 1, Pages 3-5 (July 2011)

Volume 137, Issue 1, Pages (July 2009)

Keiran S.M. Smalley Journal of Investigative Dermatology

Volume 3, Issue 4, Pages (April 2003)

Vascular Endothelial Growth Factor (VEGF) Pathway

Experimental Hematology

Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer Thomas Winder, Heinz–Josef.

Pin-Pointing a New DAP Kinase Function: The Peptidyl-Proly Isomerase Pin1 Is Negatively Regulated by DAP Kinase-Mediated Phosphorylation Shani Bialik,

Current Compensation in Neuronal Homeostasis

Regulation of Organelle Biogenesis

Proteins Kinases: Chromatin-Associated Enzymes?

p38δ and PKD1: Kinase Switches for Insulin Secretion

SRC and STAT Pathways Journal of Thoracic Oncology

The Role of PML in Tumor Suppression

Volume 14, Issue 4, Pages (October 2008)

Apoptosis Cell Volume 108, Issue 2, Pages (January 2002)

mTOR Regulation by JNK: Rescuing the Starving Intestinal Cancer Cell?

T Cell Dysfunction in Cancer

TGFβ and SMADs Talk to NANOG in Human Embryonic Stem Cells

A FIRE-y PAGE in the Computational Analysis of Cancer Profiles

Kinase signaling and targeted therapy for primary myelofibrosis

The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer: Still Following the Right TRAIL? Emmet E. McGrath, MB, PhD Journal of Thoracic.

Scleroderma Fibroblast Survival in Aktion

Apoptosis: Current Biology

Is complement a target for therapy in renal disease?

Volume 1, Issue 3, Pages (April 2002)

Jeffrey C Rathmell, Craig B Thompson Cell

Novel aspects of complement in kidney injury

Lesley-Ann Martin, Mitch Dowsett Cancer Cell

“Bak (and Bax) to the Future” — of Primary Melanoma Prognosis?

c-Raf in KRas Mutant Cancers: A Moving Target

Characterization of the MM.1 human multiple myeloma (MM) cell lines

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Turning Reciprocal Feedback Regulation into Combination Therapy

T Helper Cell Differentiation: Understanding the Needs of Hierarchy

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Volume 3, Issue 4, Pages (April 2003)

Presentation transcript:

Apoptosis-targeted therapies for cancer John C Reed Cancer Cell Volume 3, Issue 1, Pages 17-22 (January 2003) DOI: 10.1016/S1535-6108(02)00241-6

Figure 1 Apoptosis pathways Some of the better defined apoptosis pathways are depicted. FLIP, Bcl-2/Bcl-XL, and IAPs suppress specific steps in the extrinsic, intrinsic, and convergence pathways, respectively. Cancer Cell 2003 3, 17-22DOI: (10.1016/S1535-6108(02)00241-6)

Figure 2 Signal transduction and apoptosis regulation Some protein kinases and transcription factors are well known for their ability to modulate activity or expression of apoptosis-relevant proteins. The figure shows examples for (A) NFκB, (B) Akt, and (C) p53. Cancer Cell 2003 3, 17-22DOI: (10.1016/S1535-6108(02)00241-6)