HIV Latency Gets a New Histone Mark Bryan C. Nikolai, Qin Feng  Cell Host & Microbe  Volume 21, Issue 5, Pages 549-550 (May 2017) DOI: 10.1016/j.chom.2017.04.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Chromatin Modifiers as Potential Therapeutic Targets for Reversing HIV Latency Chromatin modifiers including “writer,” “reader,” and “eraser” are involved in HIV-1 latency. “Writer” is an enzyme that covalently modifies histones or DNA. “Reader” can specifically recognize chromatin modifications, whereas “eraser” can remove modifications. The Boehm et al. (2017) study indicates that SMYD2, and likely L3MBTL1, are novel regulators and pharmacological targets of HIV-1 latency. Epigenetic events under the control of host cell coregulators of HIV transcription and latency are of particular interest for “shock and kill” approaches of HIV-1 eradication for a functional cure. Cell Host & Microbe 2017 21, 549-550DOI: (10.1016/j.chom.2017.04.012) Copyright © 2017 Elsevier Inc. Terms and Conditions