Timothy R. Donahue, David W. Dawson Cell Stem Cell

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Nodal/Activin Signaling: A Novel Target for Pancreatic Cancer Stem Cell Therapy Timothy R. Donahue, David W. Dawson Cell Stem Cell Volume 9, Issue 5, Pages 383-384 (November 2011) DOI: 10.1016/j.stem.2011.10.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Nodal/Activin Signaling Maintains PDAC Stem Cells in the Tumor Stromal Microenvironment Inhibition of Alk receptor inhibitor by SB431542 blocks autocrine and potential paracrine Nodal signaling, sensitizing CSCs to chemotherapy. Inhibition of the Hedgehog pathway with CUR199691 disrupts the stroma and also may directly influence CSCs. Cell Stem Cell 2011 9, 383-384DOI: (10.1016/j.stem.2011.10.006) Copyright © 2011 Elsevier Inc. Terms and Conditions