Role of fibrinogen in trauma-induced coagulopathy

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Role of fibrinogen in trauma-induced coagulopathy D Fries, W.Z. Martini British Journal of Anaesthesia Volume 105, Issue 2, Pages 116-121 (August 2010) DOI: 10.1093/bja/aeq161 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Changes in fibrinogen synthesis and breakdown in pigs after haemorrhage, hypothermia, and acidosis. Data from Martini and colleagues17 and Martini and Holcomb.18 *P<0.05 compared with control values. British Journal of Anaesthesia 2010 105, 116-121DOI: (10.1093/bja/aeq161) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Clot firmness measured with the ROTEM system in an animal model of controlled and uncontrolled haemorrhage: MCF (in mm) at baseline (1), after removal of 65% of the estimated blood volume (2), after colloid administration (3), after substitution of fibrinogen concentrate (Fib) or placebo (Gel) (4), and after an observation period of 2 h (5).31 British Journal of Anaesthesia 2010 105, 116-121DOI: (10.1093/bja/aeq161) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Electron microscopic scan of a ×2000 magnified blood clot in a non-diluted state (a), after 65% haemodilution with gelatin (b), and after administration of fibrinogen concentrate to compensate dilutional coagulopathy (c). The administration of fibrinogen was able to compact the rarefied fibrin network again.31 British Journal of Anaesthesia 2010 105, 116-121DOI: (10.1093/bja/aeq161) Copyright © 2010 The Author(s) Terms and Conditions