Heterogeneity of Tumor Sizes in Multiple Pulmonary Metastases of Colorectal Cancer as a Prognostic Factor Tomohiro Maniwa, MD, Keita Mori, PhD, Yasuhisa.

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Heterogeneity of Tumor Sizes in Multiple Pulmonary Metastases of Colorectal Cancer as a Prognostic Factor Tomohiro Maniwa, MD, Keita Mori, PhD, Yasuhisa Ohde, MD, Takehiro Okumura, MD, Narikazu Boku, MD, PhD, Tomoyuki Hishida, MD, Yukinori Sakao, MD, Katsuo Yoshiya, MD, Ichinosuke Hyodo, MD, PhD, Haruhiko Kondo, MD The Annals of Thoracic Surgery Volume 103, Issue 1, Pages 254-260 (January 2017) DOI: 10.1016/j.athoracsur.2016.07.070 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Study design and participants. (CONSORT = Consolidated Standards of Reporting Trials; CRC = colorectal cancer; PM = pulmonary metastases; R0 = resection for cure or complete remission.) The Annals of Thoracic Surgery 2017 103, 254-260DOI: (10.1016/j.athoracsur.2016.07.070) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Overall survival rate of all patients with multiple metastases. Overall survival was 75.4% at 3 years and 58.4% at 5 years. The Annals of Thoracic Surgery 2017 103, 254-260DOI: (10.1016/j.athoracsur.2016.07.070) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Relationship between the heterogeneity of tumor sizes and risk ratios. The difference between the maximum and minimum tumor diameters (Dmax-min) of the 6 mm to 10 mm group and the Dmax-min 11 mm or more group tended to have poorer survival than the Dmax-min 0 mm to 5 mm group, with hazard ratios of 1.43 and 1.79, respectively. (CI = confidence interval.) The Annals of Thoracic Surgery 2017 103, 254-260DOI: (10.1016/j.athoracsur.2016.07.070) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Overall survival rates of patients in group A (n = 95 [dashed line]) and group B (n = 151 [solid line]). The 5-year overall survival rates were 66.5% for group A and 53.0% for group B. Overall survival differed significantly between the groups (p = 0.025). The Annals of Thoracic Surgery 2017 103, 254-260DOI: (10.1016/j.athoracsur.2016.07.070) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions