First Case of A859T Epidermal Growth Factor Receptor Mutation Responding to Erlotinib Laureline Le Maignan, BM, Delphine Mirebeau-Prunier, MD, PhD, Laurent.

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First Case of A859T Epidermal Growth Factor Receptor Mutation Responding to Erlotinib Laureline Le Maignan, BM, Delphine Mirebeau-Prunier, MD, PhD, Laurent Vervueren, MD, Thierry Jeanfaivre, MD, Thierry Urban, MD, PhD, José Hureaux, MD, PhD Journal of Thoracic Oncology Volume 6, Issue 3, Pages 639-640 (March 2011) DOI: 10.1097/JTO.0b013e3182037c0c Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Genomic DNA was isolated from paraffin-embedded tumor samples. EGFR gene exons 18, 19, 20, and 21 were each amplified by polymerase chain reactions, and the products were screened for mutations by denaturing high-performance liquid chromatography (A). An additional peak in the exon 21 amplicon was observed and direct sequencing revealed mutation p.Arg859Asp (B). Journal of Thoracic Oncology 2011 6, 639-640DOI: (10.1097/JTO.0b013e3182037c0c) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Computed tomography and positron emission tomography scans and fused images before and 8 weeks after erlotinib. Journal of Thoracic Oncology 2011 6, 639-640DOI: (10.1097/JTO.0b013e3182037c0c) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions