Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates Ange Wang,

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Presentation transcript:

Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates Ange Wang, M.D., Anthony Santistevan, M.S., Karen Hunter Cohn, Ph.D., Alan Copperman, M.D., John Nulsen, M.D., Brad T. Miller, M.D., Eric Widra, M.D., Lynn M. Westphal, M.D., Piraye Yurttas Beim, Ph.D. Fertility and Sterility Volume 108, Issue 2, Pages 254-261.e4 (August 2017) DOI: 10.1016/j.fertnstert.2017.05.007 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Effect of patient age and progesterone (P) concentration at trigger on determining the odds ratio (OR) for ongoing pregnancy for freeze-only versus fresh cycles. Patient age and P concentration at trigger modify the OR for achieving ongoing pregnancy between a freeze-only versus a fresh cycle. The 95% pointwise confidence intervals are shown in gray. The y-axes are on the natural logarithmic scale. Each panel represents the effect of P on the OR at the indicated age (labeled at the top of the panel). Fertility and Sterility 2017 108, 254-261.e4DOI: (10.1016/j.fertnstert.2017.05.007) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Propensity score matching for fresh and freeze-only cohorts. From the distribution of the propensity score and inspection of the distribution of metrics, we achieved good balance between the treatment and control groups. Fertility and Sterility 2017 108, 254-261.e4DOI: (10.1016/j.fertnstert.2017.05.007) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Receiver operating characteristic (ROC) curves for determining the optimal age and progesterone (P) concentration at trigger cutoff points. Optimal cutoff points were chosen to balance specificity and sensitivity for classifying patients as achieving ongoing pregnancy. (A) ROC curve for P at trigger. A cutoff value of 1.0 ng/mL yielded a sensitivity and specificity each equal to 0.48. (B) ROC curve for age. A cutoff value of 35 years old yielded a sensitivity and specificity each equal to 0.43. AUC = area under the curve. Fertility and Sterility 2017 108, 254-261.e4DOI: (10.1016/j.fertnstert.2017.05.007) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions