Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda,

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Presentation transcript:

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda, Véronique M. André Neuron Volume 65, Issue 2, Pages 145-147 (January 2010) DOI: 10.1016/j.neuron.2010.01.010 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Synaptic and Extrasynaptic Receptors in HD The left side shows synaptic and extrasynaptic NMDA receptors functioning in a balanced manner in the normal condition. On the right in HD there is an increase in extrasynaptic NMDA receptor function due to increase in either the number of receptors and/or an increase in extracellular glutamate that shifts the functional balance toward the extrasynaptic receptors enhancing the proapoptotic pathway. Neuron 2010 65, 145-147DOI: (10.1016/j.neuron.2010.01.010) Copyright © 2010 Elsevier Inc. Terms and Conditions