Stress Augmented Ultraviolet-Irradiation-Induced Pigmentation

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Presentation transcript:

Stress Augmented Ultraviolet-Irradiation-Induced Pigmentation Kaori Inoue, Junichi Hosoi, Ritsuro Ideta, Naomi Ohta, Ohji Ifuku, Toru Tsuchiya Journal of Investigative Dermatology Volume 121, Issue 1, Pages 165-171 (July 2003) DOI: 10.1046/j.1523-1747.2003.12326.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Effects of stress on ACTH levels. Plasma (A) and cutaneous (B) ACTH levels under control, high population density stress (10 per cage), and restraint stress (restraint) conditions. Values represent the mean of 10 animals (± SD). *p<0.001. Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effects of serum obtained from stressed animals and ACTH on tyrosinase activity in cultured human melanocytes. (A) Effects of serum obtained from stressed animals in the presence or absence of corticostatin on tyrosinase activity. (B) Dose-dependent activation of tyrosinase by ACTH. Values represent the mean±SD (n=8). *p<0.001. Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Photographs of mouse dorsal skin showing effects of stress on pigmentary response after UV irradiation. Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Effects of stress on pigmentary response after repeated UVB irradiation. Values represent the mean of 10 animals (±SD). Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Effect of stress on DOPA-stain-positive melanocytes after repeated UV irradiation. (A) Microscopic magnification of DOPA-stain-positive melanocytes in mouse dorsal epidermal sheets showing tanning response after repeated UVB irradiation for 22 d. Scale bars: 100 μm. (B) The number of DOPA-positive melanocytes after repeated UV irradiation. The columns represent numbers of DOPA-positive melanocytes. The average cell number in 30 areas led to the number per 10,000 μm2. Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 6 Effects of corticostatin on the augmentation of pigmentary response under stressful conditions after repeated UVB irradiation. Values represent the mean of five animals (±SD). Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 7 Effect of corticostatin on DOPA-stain-positive melanocytes after repeated UV irradiation. (A) Microscope magnification of DOPA-stain-positive melanocytes in mouse dorsal epidermal sheets showing the inhibition by corticostatin of pigmentary response after UV irradiation. Scale bars: 100 μm. (B) Effect of corticostatin on the number of DOPA-positive melanocytes after repeated UVB irradiation. The columns represent numbers of DOPA-positive melanocytes. The average cell number in 30 areas led to the number per 10,000 μm2. Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 8 Effects of stress on skin color. The data are representive of three experiments. Values represent the mean of 10 animals (±SD). Journal of Investigative Dermatology 2003 121, 165-171DOI: (10.1046/j.1523-1747.2003.12326.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions