Cardioplegia and vascular injury

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Presentation transcript:

Cardioplegia and vascular injury Clyde Saldanha, BSc, MB BS, FRCS (Ed), David J. Hearse, PhD, DSc The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 2, Pages 279-290 (August 1994) DOI: 10.5555/uri:pii:S0022522394700109 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Experimental preparation for perfusing and assessing vascular function in isolated rat mesentery. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Postischemic smooth muscle contractile function in response to phenylephrine (1 × 10-4 mol/L) expressed as percentage of preischemic function after 60 to 180 minutes of ischemia alone or of ischemia plus cardioplegic solution. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Vasodilation to sodium nitroprusside expressed as percent of phenylephrine-induced vasoconstriction after 60, 90, 120, 150, or 180 minutes of ischemia alone. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Vasodilation to sodium nitroprusside expressed as percent of phenylephrine-induced vasoconstriction after 60, 90, 120, 150, or 180 minutes of ischemia plus cardioplegic solution. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Vasodilation to ATP expressed as percent of phenylephrine-induced vasoconstriction after 60, 90, 120, 150, or 180 minutes of ischemia alone. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 Vasodilation to ATP expressed as percentage of phenylephrine-induced vasoconstriction after 60, 90, 120, 150, or 180 minutes of ischemia plus cardioplegic solution. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 7 Maximal postischemic responses to phenylephrine, sodium nitroprusside, and ATP after 150 minutes of ischemia with single or multiple infusionsof cardioplegic solution. Phenylephrine vasoconstrictor response is expressed as percent of preischemic response. Sodium nitroprusside and ATP vasodilator responses are expressed as percent of postischemic phenylephrine-induced vasoconstriction. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 8 Vasodilation to sodium nitroprusside expressed as percent of phenylephrine-induced vasoconstriction before and after 150 minutes of ischemia with single or multiple infusions of cardioplegic solution. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 9 Vasodilation to ATP expressed as percent of phenylephrine-induced vasoconstriction before and after 150 minutes of ischemia with single or multiple infusions of cardioplegic solution. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 279-290DOI: (10.5555/uri:pii:S0022522394700109) Copyright © 1994 Mosby, Inc. Terms and Conditions