Thymoma and Thymic Carcinoma: Molecular Pathology and Targeted Therapy

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Thymoma and Thymic Carcinoma: Molecular Pathology and Targeted Therapy Philipp Ströbel, MD, Peter Hohenberger, MD, Alexander Marx, MD Journal of Thoracic Oncology Volume 5, Issue 10, Pages S286-S290 (October 2010) DOI: 10.1097/JTO.0b013e3181f209a8 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 A, Age distribution of thymomas (n= 815) and thymic carcinomas (n = 128) showing similar age peaks for the fifth to sixth decade. B, In patients younger than 30 years at primary diagnosis, most thymic epithelial tumors belonged to the malignant categories. Journal of Thoracic Oncology 2010 5, S286-S290DOI: (10.1097/JTO.0b013e3181f209a8) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Molecular genetic routes in thymomas and thymic carcinomas. Genetic alterations of chr. 6q25 are found in all entities, suggesting the presence of a “gatekeeper” mutation in a common progenitor cell. Type AB, B2, and B3 thymomas show some genetic similarities with respect to common alterations. Part of B3 thymomas may develop along an alternative route, as indicated by the presence of mutations within the APC, RB, and TP53 gene locus, which is in good agreement with their slightly more aggressive behavior compared with type B2. Thymic carcinomas not only show some genetic overlap with B3 thymomas, namely gain of chromosome 1q and losses of chromosome 16q, but also show additional recurrent alterations that are not found in B3 thymomas. Journal of Thoracic Oncology 2010 5, S286-S290DOI: (10.1097/JTO.0b013e3181f209a8) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions