Comparison between early and late carotid endarterectomy for symptomatic carotid stenosis in relation to oxidized low-density lipoprotein and plaque vulnerability

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Comparison between early and late carotid endarterectomy for symptomatic carotid stenosis in relation to oxidized low-density lipoprotein and plaque vulnerability Atsuhiko Suzue, MD, Masaaki Uno, MD, Keiko T. Kitazato, BS, Kyoko Nishi, MD, Kenji Yagi, MD, Hao Liu, MD, Tetsuya Tamura, MD, Shinji Nagahiro, MD Journal of Vascular Surgery Volume 46, Issue 5, Pages 870-875 (November 2007) DOI: 10.1016/j.jvs.2007.06.039 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Distribution of the timing of carotid endarterectomy after the last neurologic symptoms in groups A and B. Journal of Vascular Surgery 2007 46, 870-875DOI: (10.1016/j.jvs.2007.06.039) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 Plaques and plasma oxidized low-density lipoprotein (OxLDL) levels in group A and B patients. *P < .05. Journal of Vascular Surgery 2007 46, 870-875DOI: (10.1016/j.jvs.2007.06.039) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 A, Ratio of vulnerable plaques in each group (A, group A; B, group B). *P < .05. B, Plaque oxidized low-density lipoprotein (OxLDL) level in each group. **P < .01. C, Plaque matrix metalloproteinase (MMP)-9 activity in groups A and B. D, Plaque MMP-9 activity in each group. *P < .05. E, Plaque zymography in each group. The individual three experiments were repeated in each plaque sample. MMP-9 was strongly positive in groups Av and Bv. M, maker (positive control). Journal of Vascular Surgery 2007 46, 870-875DOI: (10.1016/j.jvs.2007.06.039) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 4 Matrix metalloproteinase (MMP)-9 and oxidized low-density lipoprotein (OxLDL) staining of vulnerable plaques in groups Av and Bv. In sequential specimens from each plaque sample, the immunostaining against each antigen was performed at least two times. Journal of Vascular Surgery 2007 46, 870-875DOI: (10.1016/j.jvs.2007.06.039) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 5 Matrix metalloproteinase (MMP)-9 and oxidized low-density lipoprotein (OxLDL) staining of stable plaques in groups As and Bs. In sequential specimens from each plaque sample, the immunostaining against each antigen was performed at least two times. Journal of Vascular Surgery 2007 46, 870-875DOI: (10.1016/j.jvs.2007.06.039) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions