Improving the life-time of dental composites (Thiourethanes oligomers improve properties of methacrylate-based dental restorative materials) Carmem Pfeifer, DDS, PhD pfeiferc@ohsu.edu Michelle Gunness, PhD, CLP gunnessm@ohsu.edu © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 1

Executive Overview We, at the Biomaterials and Biomechanics Division at OHSU, have developed a simple additive that will improve the life-time of tooth-colored restorations. This additive provides better resistance to fracture and more reliable adhesion to tooth structure, without the need to change the techniques dentists are currently using to restore teeth, which makes the ROI (return on investment) potentially very short. Ultimately, improving current esthetic materials will make them last as long as amalgam restorations, without the mercury exposure to patients. © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 2

Unmet Need Tooth-colored restorations made with dental composites have become more common as they replace amalgam metal fillings Unfortunately, composite restorations last only about 5-10 years, forcing their replacement. Not only is this costly for the patient, but it also increases discomfort and makes the original cavity larger. Reasons for failure: Fracture Debonding (stress) © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 3

The Science Additives synthesized through a simple method in our lab have shown to increase fracture toughness and decrease the stress at the interface of such restorations Potential for improving the life-time of dental composites in the clinic Potential applications in coatings industry (reduced interfacial stress) © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 4a

The Science Toughness and crosslinking density define the probability of a material resisting crack propagation and fracture when in service. The materials modified by these additives (only 6% of the total mass of composite) present significantly higher toughness and crosslinking density, as well as other improvements in mechanical properties. © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 4b

The Science Stress decreases of up to 60% are observed in spite of the maintenance/increase in conversion. Clinically, this means that the interface tooth-restoration is not as challenged as in current materials - increases in bond strength have also been observed. © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 4c

The Science No need to change the current operatory technique – potentially short return on investment For selected compositions, lower stress is achieved at the same time mechanical properties increase – unparalleled in the current market High molecular weight – ODORLESS High refractive index – optical clarity Thio-urethane bonds are more stable than ester bonds in terms of hydrolitic degradation – more biocompatible Platform for other applications? © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 4d

Project Management TECHNOLOGY/IP Protected under PCT/US15/21016 (PIs: Pfeifer and Ferracane) for dental application PI Carmem Pfeifer, DDS, PhD – background in polymer chemistry and dental materials (fully equipped lab for chemical synthesis and mechanical testing) Other faculty Jack Ferracane, PhD – background in mechanical testing and biofilm formation/biocompatibility testing Fully committed personnel to related projects in the lab 2 post-doctoral associates (chemist/PhD; DDS/PhD) 2 senior research assistants (chemist; biologist) 2 research assistants (chemist; chemical engineer) 7 graduate students (working towards PhD in Dental Materials) © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 5

Need longer lasting restorations Momentum Need longer lasting restorations These will benefit millions of patients whose restorations are replaced every year, halting disease progression and preventing more costly interventions. Market Opportunity & Competition US market for dental materials: over $1 billion as of 2013 (with direct sales). Growth by 2020 to $1.5 billion. Dental composites are a significant part of this market – no product currently can achieve high conversion/mechanical properties and low interfacial stress at the same time. This can be achieved by this technology without disruption to current dental technique/infra-structure – short ROI © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 6a

Momentum Can potentially be used in other polymer applications where stress management is important UV Coatings 3D printing Molded parts Ink/paints Others? At least two fundamental fields of use © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 6b

The Ask Viability NO NEED TO REINVENT THE WHEEL – SHORT ROI Create a company Too premature at this stage? Licensing partnership Currently having discussions Open to new business partners R&D partnership For clinical trials For non-dental related application © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 7

Contact information Carmem Pfeifer, DDS, PhD OHSU School of Dentistry 2730 SW Moody Ave, Portland, OR, 97201 CLSB room 6N036 503-494-3288 pfeiferc@ohsu.edu © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 7

Contact information Courtesy of Dr. Tom Hilton, Dr. Walter G. Miranda Jr and Dr. Carlos Francci http://rhdentistry.com/dental-care-richmond-hill/orthodontic-and-cosmetic/teeth-whitening/ http://www.smilecenterclinics.com/cosmetic-dentistry/teeth-whitening http://www.researchandmarkets.com/research/fk6vct/u_s_market_for © 2015 Carmem Pfeifer/OHSU – ALL RIGHTS RESERVED Slide 7