Volume 367, Issue 9518, Pages (April 2006)

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Volume 367, Issue 9518, Pages 1247-1255 (April 2006) Sustained efficacy up to 4·5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial Prof Diane M Harper, MD, Prof Eduardo L Franco, PhD, Prof Cosette M Wheeler, PhD, Prof Anna-Barbara Moscicki, MD, Barbara Romanowski, MD, Cecilia M Roteli-Martins, MD, Prof David Jenkins, MD, Anne Schuind, MD, Sue Ann Costa Clemens, MD, Gary Dubin, MD The Lancet Volume 367, Issue 9518, Pages 1247-1255 (April 2006) DOI: 10.1016/S0140-6736(06)68439-0 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Trial design Follow-up time for each woman in each study phase varies dependent on when she completed her last study visit in the initial efficacy study and when she entered the extended follow-up phase. The Lancet 2006 367, 1247-1255DOI: (10.1016/S0140-6736(06)68439-0) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 2 Geometric mean titres and seropositivity rates, according to HPV type and group in according-to-protocol analyses for immunogenicity %=proportion of women seropositive. Sera from all vaccinees and a small number of samples from the placebo group of the initial study were retested. The Lancet 2006 367, 1247-1255DOI: (10.1016/S0140-6736(06)68439-0) Copyright © 2006 Elsevier Ltd Terms and Conditions