Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second- generation Asians suggest genetic regulation of eosinophilia Mahboobeh.

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Presentation transcript:

Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second- generation Asians suggest genetic regulation of eosinophilia Mahboobeh Mahdavinia, MD, PhD, Lydia A. Suh, MSc, Roderick G. Carter, BS, Whitney W. Stevens, MD, PhD, James E. Norton, MSc, Atsushi Kato, PhD, Bruce K. Tan, MD, Robert C. Kern, MD, David B. Conley, MD, Rakesh Chandra, MD, Jennifer Lavin, MD, Anju T. Peters, MD, Leslie C. Grammer, MD, Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology Volume 135, Issue 2, Pages 576-579 (February 2015) DOI: 10.1016/j.jaci.2014.08.031 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, The ECP level in polyp tissue homogenates was significantly lower in samples from Asian patients than in samples from white patients. B, Also, the ECP level in UT of Asian cases was significantly lower than the ECP level in UT extracts of both white and black patients. C, Asian patients had a significantly lower frequency of pathology-reported eosinophilic sinusitis than did patients of other ethnicities. D, The ECP level in polyp extracts was significantly lower in cases reported in the surgical pathology examination as noneosinophilic than in those reported as eosinophilic. Asian patients with CRS and nasal polyposis had a significantly lower frequency of atopy (E) and a trend toward lower frequency of asthma compared with white and black patients. (*P < .05). Journal of Allergy and Clinical Immunology 2015 135, 576-579DOI: (10.1016/j.jaci.2014.08.031) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions