Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration Kana Matsumoto, Naoyuki Uchida, Amane Sakurai,

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Presentation transcript:

Clinical Application of the Dried Blood Spot Method in the Measurement of Blood Busulfan Concentration Kana Matsumoto, Naoyuki Uchida, Amane Sakurai, Shuichi Taniguchi, Kunihiko Morita Biology of Blood and Marrow Transplantation Volume 22, Issue 11, Pages 1968-1973 (November 2016) DOI: 10.1016/j.bbmt.2016.07.008 Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Correlation between the DBS method and conventional method for busulfan (A) concentration and (B) AUC0–∞. Blood samples for analysis were collected at 2, 4, and 6 hours after the start of infusion. Correlation coefficients for A and B were R2 = .9837 (y = .9903x, P < .01) and R2 = .8725 (y = 0.9986x, P < .01), respectively. Sampling was from 10 patients. Biology of Blood and Marrow Transplantation 2016 22, 1968-1973DOI: (10.1016/j.bbmt.2016.07.008) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Effects of hematocrit value on the divergence between blood busulfan concentrations obtained with the DBS method and conventional method (y = .2847x − 8.1196, R2 = .0539, P = .52). The hematocrit range was 18.2% to 34.1%. Biology of Blood and Marrow Transplantation 2016 22, 1968-1973DOI: (10.1016/j.bbmt.2016.07.008) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions