Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82  Robert Lafyatis, Julio C. Mantero, Jessica Gordon, Nina Kishore, Mary Carns, Howard Dittrich, Robert Spiera, Robert W. Simms, John Varga  Journal of Investigative Dermatology  Volume 137, Issue 12, Pages 2473-2483 (December 2017) DOI: 10.1016/j.jid.2017.06.032 Copyright © 2017 The Authors Terms and Conditions

Figure 1 CONSORT flow diagram. Diagram illustrates screening, enrollment, allocation of study participants, and analysis. Journal of Investigative Dermatology 2017 137, 2473-2483DOI: (10.1016/j.jid.2017.06.032) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Hierarchical clustering of gene expression changes. The cluster includes genes that were found to be differentially expressed in C-82–treated skin compared with placebo. Clustering by gene is unsupervised and by patient is supervised. Gene symbols are shown to the right. Red indicates increased and green indicates decreased gene expression (fold change in C-82–treated skin compared with placebo). Journal of Investigative Dermatology 2017 137, 2473-2483DOI: (10.1016/j.jid.2017.06.032) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Gene Ontology biological process. Gene Ontology biological processes enrichment analysis was performed on the cluster of 212 up-regulated genes that were found to be differentially expressed in the C-82–treated skin. Results show that these genes are associated with cellular, cholesterol, isoprenoid, and long-chain fatty-acyl-CoA biosynthetic processes commonly observed in adipocytes. Journal of Investigative Dermatology 2017 137, 2473-2483DOI: (10.1016/j.jid.2017.06.032) Copyright © 2017 The Authors Terms and Conditions