Volume 28, Issue 2, Pages R66-R68 (January 2018) Mitophagy: Vps13D Couples Mitochondrial Fission and Autophagic Clearance  Zheng Wang, Hong Zhang  Current Biology  Volume 28, Issue 2, Pages R66-R68 (January 2018) DOI: 10.1016/j.cub.2017.12.017 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Vps13D regulates mitochondrial fission to control mitophagy. Upon mitophagy induction, mitochondria destined for degradation are labeled by K63-ubiquitin chains, fragmented by mitochondrial fission factors and engulfed by autophagosomes, called mitophagosomes. Vps13D is involved in mitochondrial fission in a manner that depends on its ubiquitin-binding UBA domain. If Vps13D is depleted, or its ubiquitin-binding activity is impaired, mitochondria accumulate and enlarge in midgut cells and are not degraded, even though they are labeled with ubiquitin. The mitochondrial fission protein Drp1 accumulates on mitochondria in Vps13D-depleted cells. Knockdown of mitochondrial fusion factors rescues the mitochondrial phenotype, indicating that Vps13D functions at the step downstream of mitochondrial fission in mitophagy. Current Biology 2018 28, R66-R68DOI: (10.1016/j.cub.2017.12.017) Copyright © 2017 Elsevier Ltd Terms and Conditions