Inhibition of experimental neointimal hyperplasia and neoatherosclerosis by local, stent- mediated delivery of everolimus Hugh Q. Zhao, PhD, Alexander.

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Inhibition of experimental neointimal hyperplasia and neoatherosclerosis by local, stent- mediated delivery of everolimus Hugh Q. Zhao, PhD, Alexander Nikanorov, MD, PhD, Renu Virmani, MD, Lewis B. Schwartz, MD Journal of Vascular Surgery Volume 56, Issue 6, Pages 1680-1688 (December 2012) DOI: 10.1016/j.jvs.2012.04.022 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 1 The Dynalink-E everolimus-eluting self-expanding stent. Journal of Vascular Surgery 2012 56, 1680-1688DOI: (10.1016/j.jvs.2012.04.022) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 2 In vivo profile of everolimus release from the drug-polymer coating on the Dynalink-E nitinol self-expanding stent. Journal of Vascular Surgery 2012 56, 1680-1688DOI: (10.1016/j.jvs.2012.04.022) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 3 In vivo everolimus concentrations in whole blood, stented arteries, and unstented (adjacent) arterial tissues after implantation of the Dynalink-E drug-eluting stent (DES). LLOQ, Lower limit of quantitation. Journal of Vascular Surgery 2012 56, 1680-1688DOI: (10.1016/j.jvs.2012.04.022) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 4 Whole-mount example histophotomicrographs of overlapped bare metal stent (BMS) or drug-eluting stent (DES) in porcine iliac arteries after 3 months (left panels), 6 months (middle panels), and 12 months (right panels). Sections are stained with toluidine blue and basic fuchsin. Journal of Vascular Surgery 2012 56, 1680-1688DOI: (10.1016/j.jvs.2012.04.022) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 5 Histologic examples of stent-inducted neoatherosclerosis. a, Bare metal stent (BMS) at 3 months. Note the presence of severe neoatherosclerosis, including cholesterol clefts visible as void spaces, surrounding foamy cell accumulation, and fat infiltration. b, BMS at 6 months. c, BMS at 12 months. d, Drug-eluting stents (DES) at 12 months. Sections were stained with toluidine blue basic fuchsin. Journal of Vascular Surgery 2012 56, 1680-1688DOI: (10.1016/j.jvs.2012.04.022) Copyright © 2012 Society for Vascular Surgery Terms and Conditions