Transforming Lipoxygenases: PE-Specific Enzymes in Disguise

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Transforming Lipoxygenases: PE-Specific Enzymes in Disguise Ling F. Ye, Brent R. Stockwell Cell Volume 171, Issue 3, Pages 501-502 (October 2017) DOI: 10.1016/j.cell.2017.10.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 PEBP1 Associates with Lipoxygenases and Allows Them to Generate a Specific Lipid Peroxide that Promotes Ferroptosis (A) The unbound enzyme acts on free fatty acids. (B) Bound to PEBP1, lipoxygenases acquire the ability to convert membrane phosphatidylethanolamine (PE) to its oxidized form, leading to ferroptotic cell death. Cell 2017 171, 501-502DOI: (10.1016/j.cell.2017.10.006) Copyright © 2017 Elsevier Inc. Terms and Conditions