The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs Patrick Micke,

Slides:

Advertisements

Similar presentations

Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,

Advertisements

Primary Small Cell Carcinoma of the Esophagus Jima Lv, MD, Jun Liang, MD, Jinwan Wang, MD, Luhua Wang, MD, Jie He, MD, Zefen Xiao, MD, Weibo Yin, MD Journal.

A Prognostic Scoring Model for the Utility of Induction Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in Esophageal Cancer Mian Xi, MD, Zhongxing.

Naomi Fujioka, MD, Christopher A. French, MD, Michael J

Primary cutaneous mucinous carcinoma of the breast

Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies Sai-Hong Ignatius Ou, MD,

Brain Radionecrosis Treated with Bevacizumab in a Patient with Resected Squamous Cell Carcinoma of the Lung Jordi Remon, MD, Cécile Le Péchoux, MD, Caroline.

Accuracy of Fine Needle Aspiration Cytology in the Pathological Typing of Non-small Cell Lung Cancer Rita Nizzoli, PhD, Marcello Tiseo, MD, Francesco.

Chia-Lin Hsu, MD, Kuan-Yu Chen, MD, PhD Journal of Thoracic Oncology

The eighth edition TNM stage classification for lung cancer: What does it mean on main street? Frank C. Detterbeck, MD The Journal of Thoracic and Cardiovascular.

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib Nobukazu Agatsuma, MD Journal of.

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib Nobukazu Agatsuma, MD Journal of.

Response to Crizotinib/Erlotinib Combination in a Patient with a Primary EGFR-Mutant Adenocarcinoma and a Primary c-met–Amplified Adenocarcinoma of the.

SC17.02 Lung Cancer in China: Challenges and Perspectives

A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer Shinjiro.

ΔNp63 (p40) and Thyroid Transcription Factor-1 Immunoreactivity on Small Biopsies or Cellblocks for Typing Non-small Cell Lung Cancer: A Novel Two-Hit,

Y-L Chang, MD, C-T Wu, MD, Y-C Lee, MD, PhD

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification Anna Karlsson, MSc,

Incidence of Brain Metastasis at the Initial Diagnosis of Lung Squamous Cell Carcinoma on the Basis of Stage, Excluding Brain Metastasis Hyun Lee, MD,

Joachim Pfannschmidt, MD, Hans Hoffmann, MD, Hendrick Dienemann, MD

KRAS Mutation Analysis Helps to Differentiate Between Pulmonary Metastasis from Colon Adenocarcinoma In Situ and Primary Lung Adenocarcinoma Taylor M.

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification Anna Karlsson, MSc,

Prognostic Impact of Margin Distance and Tumor Spread Through Air Spaces in Limited Resection for Primary Lung Cancer Kyohei Masai, MD, Hiroyuki Sakurai,

Treatment of Pulmonary Epithelioid Hemangioendothelioma with Bevacizumab Young Hak Kim, MD, Michiaki Mishima, MD, PhD, Aya Miyagawa-Hayashino, MD, PhD

Electronic Updates for JTO Readers

IA05.01 Lung Cancer Cases Journal of Thoracic Oncology

An Unusual Presentation of Malignant Pleural Mesothelioma

Frank Detterbeck, MD Journal of Thoracic Oncology

Assessment of the ITMIG Statement on the WHO Histological Classification and of the Eighth TNM Staging of Thymic Epithelial Tumors of a Series of 188.

Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities Matthew P. Humphries, PhD, Stephen.

Surgical Treatment of a Giant Symptomatic Cardiac Lipoma

A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib Parneet K. Cheema, MD, MBiotech, FRCPC Journal.

Pulmonary Blastoma with Renal Metastasis Responds to Sorafenib

Histologic Transformation in NSCLC with PD-1 therapy

Lung Cancer and Prognosis in Taiwan: A Population-Based Cancer Registry Bing-Yen Wang, MD, Jing-Yang Huang, Ching-Yuan Cheng, MD, Ching-Hsiung Lin, MD,

Association between Congenital Lung Malformations and Lung Tumors in Children and Adults: A Systematic Review Arianna Casagrande, MD, Federica Pederiva,

Ritbune Prakobkit, MD, William Churk-Nam Auyeung, MD

Elizabeth B. Gottlin, PhD, Rex C. Bentley, MD, Michael J

Lung Cancer Patients with Germline Mutations Detected by Next-Generation Sequencing and/or Liquid Biopsy Takehito Shukuya, MD, PhD, Sandipkumar Patel,

Strategies to Improve Outcomes of Patients with EGFR-Mutant Non–Small Cell Lung Cancer: Review of the Literature Caicun Zhou, MD, PhD, Luan Di Yao, MD

The correlation between tumor size and lymphatic vessel invasion in resected peripheral stage I non-small-cell lung cancer Yukito Ichinose, MDa, Tokujiro.

Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer Patrick Micke, MD, PhD, Karolina Edlund,

Impact of positive pleural lavage cytology on survival in patients having lung resection for non–small-cell lung cancer: An international individual patient.

A Different Method in Diagnosis of Multiple Primary Lung Cancer

Survival Differences by Gender for Resected Non-small Cell Lung Cancer: A Retrospective Analysis of 12,509 Cases in a Japanese Lung Cancer Registry Study

Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response

Loss of p16INK4A Expression and Homozygous CDKN2A Deletion Are Associated with Worse Outcome and Younger Age in Thymic Carcinomas Scott W. Aesif, MD,

Prognostic Impact of Node Involvement Pattern in Pulmonary pN1 Squamous Cell Carcinoma Patients Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Genichiro.

Vamsidhar Velcheti, MD Journal of Thoracic Oncology

Tracheal Mucoepidermoid Carcinoma

ALK Translocation in Non-small Cell Lung Cancer with Adenocarcinoma and Squamous Cell Carcinoma Markers Samuel J. Klempner, MD, David W. Cohen, MD, Daniel.

An Unmet Need in the WHO 2015 Biopsy Classification: Poorly Differentiated NSCCs with Positive Neuroendocrine Markers Jules L. Derks, MD Journal of.

Aglaya G. Iyevleva, MD, PhD Journal of Thoracic Oncology

Osimertinib for Epidermal Growth Factor Receptor Mutation–Positive Lung Adenocarcinoma That Transformed to T790M-Positive Squamous Cell Carcinoma Naoyuki.

Carlie S. Sigel, MD, Andre L. Moreira, MD, PhD, William D

Nivolumab-Induced Granulomatous Inflammation of the Pleura

Histological Subtypes of Lung Adenocarcinoma Have Differential 18F- Fluorodeoxyglucose Uptakes on the Positron Emission Tomography/Computed Tomography.

David H. Hwang, MD, Lynette M. Sholl, MD, Vanesa Rojas-Rudilla, M

Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor–Resistant Non–Small Cell Lung Cancer Hiroaki Ogata,

Pulmonary Metastasectomy in Breast Cancer

A Prognostic Scoring Model for the Utility of Induction Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in Esophageal Cancer Mian Xi, MD, Zhongxing.

Biclonal Non-small Cell Lung Cancer in Disseminated Tumor Cells and Tissue Anna Puggina, MSc, Verena Kümmerlen, MD, Korinna Jöhrens-Leder, MD, Ulrich.

Genetic Changes in Squamous Cell Lung Cancer: A Review

EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers

Journal of Thoracic Oncology

Influence of Ground Glass Opacity and the Corresponding Pathological Findings on Survival in Patients with Clinical Stage I Non–Small Cell Lung Cancer

Who should decide margin length in pulmonary excision of lung cancer?

A B3 Type-Thymoma in a 7-Year-Old Child with Myasthenia Gravis

Robert Comis, MD, The Passing of a “Lung Man”

Reply to “Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non–Small Cell Lung Cancer: Methodological Issues” Boris Sepesi,

Presentation transcript:

The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs Patrick Micke, MD, PhD, Johanna Sofia Margareta Mattsson, MSc, Dijana Djureinovic, MSc, Björn Nodin, PhD, Karin Jirström, MD, PhD, Lena Tran, BSc, Per Jönsson, MD, PhD, Maria Planck, MD, PhD, Johan Botling, MD, PhD, Hans Brunnström, MD, PhD Journal of Thoracic Oncology Volume 11, Issue 6, Pages 862-872 (June 2016) DOI: 10.1016/j.jtho.2016.01.020 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Two cases of squamous cell carcinomas with a partly pseudoadenocarcinomatous appearance, originally suggested to be adenosquamous carcinomas on the basis of morphology alone. (A–C) Case 1 and (D–F) case 2. (A and D) Hematoxylin and eosin (B and E), CK5, and (C and F) TTF-1 staining. In both cases, the results of p40 and p63 staining were also positive, whereas that of napsin A staining was negative. Journal of Thoracic Oncology 2016 11, 862-872DOI: (10.1016/j.jtho.2016.01.020) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 A case of solid adenocarcinoma with mucin production in which the results of staining were positive for p63 and negative for all other markers (see the text for details). (A) Hematoxylin and eosin, (B) periodic acid-Schiff with diastase, (C) p63, and (D) TTF-1 staining. The results of staining with CK5, p40, and napsin A were also negative. Journal of Thoracic Oncology 2016 11, 862-872DOI: (10.1016/j.jtho.2016.01.020) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Two cases of so-called pseudosquamous adenocarcinoma originally diagnosed as poorly differentiated squamous cell carcinoma on the basis of morphology alone. (A–C) Case 1 and (D–F) case 2. (A and D) Hematoxylin and eosin, (B and E) CK5, and (C and F) TTF-1 staining. In both cases, the result of staining with napsin A was also positive, whereas that of staining with p40 was negative. Journal of Thoracic Oncology 2016 11, 862-872DOI: (10.1016/j.jtho.2016.01.020) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions