DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey

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DNA Double-Strand Break Repair: A Relentless Hunt Uncovers New Prey JoAnn M. Sekiguchi, David O. Ferguson Cell Volume 124, Issue 2, Pages 260-262 (January 2006) DOI: 10.1016/j.cell.2006.01.010 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Nonhomologous End-Joining in Mammalian Cells The Ku70/Ku80 heterodimer forms a hollow ring that preferentially binds to DNA ends. Ku70/Ku80 bound to DNA ends recruits DNA-PKcs, which forms a complex with the Artemis nuclease. DNA-PKcs may tether the ends, while Artemis nucleolytically processes DNA ends prior to joining. The Cernunnos-XLF protein forms complexes with XRCC4, Ligase IV, or XRCC4 and Ligase IV simultaneously. The exact nature of the active complex is currently undefined, but could involve the formation of heteromultimers with XRCC4 or the XRCC4-Ligase IV complex. The final stage of NHEJ is the ligation of DNA ends catalyzed by XRCC4-Ligase IV. Cernunnos-XLF promotes this process in an unknown way. Cell 2006 124, 260-262DOI: (10.1016/j.cell.2006.01.010) Copyright © 2006 Elsevier Inc. Terms and Conditions