The effects of low-dose radiation on neointimal hyperplasia

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The effects of low-dose radiation on neointimal hyperplasia T.P. Sarac, MD, P.N. Riggs, MD, J.P. Williams, PhD, R.H. Feins, MD, R. Baggs, DVM, PhD, P. Rubin, MD, R.M. Green, MD Journal of Vascular Surgery Volume 22, Issue 1, Pages 17-24 (July 1995) DOI: 10.1016/S0741-5214(95)70083-8 Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Schematic of radiation catheter sitting on top of injured CCA, demonstrating that 192Ir HDRB is given to localized area. Actual size of the 192Ir is 1.5 mm × 5 mm. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Dosimetry gradient of radiation at 10 Gy, illustrating drop off in dose over distance. Numbers inside ellipse represent dose fall off 2 mm from target zero. Figure illustrates that entire vessel received uniform dose of radiation. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Light micrographs of CCA. (PAS; original magnification ×35.) A, Untreated rat subjected to balloon injury; note intimal thickening. B, Contralateral untreated and uninjured CCA; note lack of medial degeneration. C, CCA treated with radiation at 10 Gy after balloon injury; vessel is indistinguishable from B. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Light micrographs of CCA. (PAS; original magnification ×35.) A, Untreated rat subjected to balloon injury; note intimal thickening. B, Contralateral untreated and uninjured CCA; note lack of medial degeneration. C, CCA treated with radiation at 10 Gy after balloon injury; vessel is indistinguishable from B. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Light micrographs of CCA. (PAS; original magnification ×35.) A, Untreated rat subjected to balloon injury; note intimal thickening. B, Contralateral untreated and uninjured CCA; note lack of medial degeneration. C, CCA treated with radiation at 10 Gy after balloon injury; vessel is indistinguishable from B. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Irradiated animals had significantly less Evans blue uptake into vessel wall, p < 0.05. Middle blue column represents length of vessel stained with Evans Blue and indicates absence of functioning endothelium. Proximal white and distal white columns refer to lengths of reendothelialized vessels at each end of injury. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Scanning electron micrograph. (Original magnification ×1400.) CCA treated at 10 Gy. Sheets of endothelial cells are present and oriented in direction of flow, which is typical of normal functioning endothelial layer. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Transmission electron micrographs. A, Untreated rat subjected to balloon injury. (Original magnification ×4400.) B, Contralateral untreated and uninjured CCA (Original magnification ×7040); note intact internal elastic lamina. C, CCA treated with radiation at 10 Gy after balloon injury. (Original magnification ×4400.) Note “endothelial-like” cells, no necrotic material in media and lack of intimal thickening. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Transmission electron micrographs. A, Untreated rat subjected to balloon injury. (Original magnification ×4400.) B, Contralateral untreated and uninjured CCA (Original magnification ×7040); note intact internal elastic lamina. C, CCA treated with radiation at 10 Gy after balloon injury. (Original magnification ×4400.) Note “endothelial-like” cells, no necrotic material in media and lack of intimal thickening. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Transmission electron micrographs. A, Untreated rat subjected to balloon injury. (Original magnification ×4400.) B, Contralateral untreated and uninjured CCA (Original magnification ×7040); note intact internal elastic lamina. C, CCA treated with radiation at 10 Gy after balloon injury. (Original magnification ×4400.) Note “endothelial-like” cells, no necrotic material in media and lack of intimal thickening. Journal of Vascular Surgery 1995 22, 17-24DOI: (10.1016/S0741-5214(95)70083-8) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions