Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains Till Maurer, Ingrid E. Wertz Molecular Cell

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Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains Till Maurer, Ingrid E. Wertz Molecular Cell Volume 63, Issue 1, Pages 4-6 (July 2016) DOI: 10.1016/j.molcel.2016.06.027 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Interactions between MINDY-1 Domains and K48-Linked Polyubiquitin The MINDY-1 catalytic domain is depicted interacting with K48-linked tri-ubiquitin, as are the tandem MIU domains. The catalytic triad is shown in red font and is positioned to cleave the distal ubiquitin moiety. Additional substrate-binding domains and substrate proteins remain to be identified. Molecular Cell 2016 63, 4-6DOI: (10.1016/j.molcel.2016.06.027) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Deubiquitinase Cleavage Modes Please see text for more details. Molecular Cell 2016 63, 4-6DOI: (10.1016/j.molcel.2016.06.027) Copyright © 2016 Elsevier Inc. Terms and Conditions