Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged.

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Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged female subjects Emily J. Blake, M.D., Paul M. Norris, M.D., Sally Faith Dorfman, M.D., MSHSA., James Longstreth, Ph.D., Vladimir I. Yankov, M.D. Fertility and Sterility Volume 94, Issue 4, Pages 1296-1301 (September 2010) DOI: 10.1016/j.fertnstert.2009.06.014 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Single-day treatment phase: mean (±SEM) serum progesterone concentrations (ng/mL). Fertility and Sterility 2010 94, 1296-1301DOI: (10.1016/j.fertnstert.2009.06.014) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Days 1–5 of the multiple-day treatment phase: mean (±SEM) serum progesterone trough concentrations (ng/mL). Fertility and Sterility 2010 94, 1296-1301DOI: (10.1016/j.fertnstert.2009.06.014) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Day 5 of the multiple-day treatment phase: mean (±SEM) serum progesterone concentrations (ng/mL). Fertility and Sterility 2010 94, 1296-1301DOI: (10.1016/j.fertnstert.2009.06.014) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions