Volume 137, Issue 5, Pages 1609-1620.e3 (November 2009) A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers  Katsuhiko Nosho, Shoko Kure, Natsumi Irahara, Kaori Shima, Yoshifumi Baba, Donna Spiegelman, Jeffrey A. Meyerhardt, Edward L. Giovannucci, Charles S. Fuchs, Shuji Ogino  Gastroenterology  Volume 137, Issue 5, Pages 1609-1620.e3 (November 2009) DOI: 10.1053/j.gastro.2009.08.002 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Synchronous colorectal cancer cases and solitary cancer controls in a background of well-defined prospective cohort studies. Gastroenterology 2009 137, 1609-1620.e3DOI: (10.1053/j.gastro.2009.08.002) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Kaplan–Meier curves for colorectal cancer-specific survival (top panel) and overall survival (bottom panel) according to synchronicity status. Gastroenterology 2009 137, 1609-1620.e3DOI: (10.1053/j.gastro.2009.08.002) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Correlation of LINE-1 methylation levels in synchronous colorectal cancer pairs. Each dot represents a synchronous tumor pair indicated by “location of Tumor 1”/“location of Tumor 2.” Red font indicates tumor pairs in discordant anatomic locations (ie, proximal colon vs distal colorectum). *Tumor 1 refers to a tumor at a higher stage or a larger tumor if the 2 synchronous tumors were at the same stage. D, distal colon (splenic flexure to sigmoid); P, proximal colon (cecum to transverse colon); R, rectum. Gastroenterology 2009 137, 1609-1620.e3DOI: (10.1053/j.gastro.2009.08.002) Copyright © 2009 AGA Institute Terms and Conditions