CD19+CD21low B Cells and CD4+CD45RA+CD31+ T Cells Correlate with First Diagnosis of Chronic Graft-versus-Host Disease Hildegard T. Greinix, Zoya Kuzmina,

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CD19+CD21low B Cells and CD4+CD45RA+CD31+ T Cells Correlate with First Diagnosis of Chronic Graft-versus-Host Disease Hildegard T. Greinix, Zoya Kuzmina, Roman Weigl, Ulrike Körmoczi, Arno Rottal, Daniel Wolff, Mateja Kralj, Peter Kalhs, Margit Mitterbauer, Werner Rabitsch, Matthias Edinger, Ernst Holler, Winfried F. Pickl Biology of Blood and Marrow Transplantation Volume 21, Issue 2, Pages 250-258 (February 2015) DOI: 10.1016/j.bbmt.2014.11.010 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Increased percentages of CD19+CD21low B cells (Left), absolute numbers of CD4+ T cells (Center), and percentages of CD4+CD45RA+ naïve T cells (Right) analyzed on day 100 after hematopoietic cell transplantation are significantly associated with later development of chronic graft-versus-host disease (cGVHD). Results in patients never experiencing cGVHD (No cGVHD cohort) are compared with those in patients experiencing cGVHD at later time points (cGVHD cohort). Data are shown in box plots. ● represents outliers. □ represents mean, line in the box represents the median. Biology of Blood and Marrow Transplantation 2015 21, 250-258DOI: (10.1016/j.bbmt.2014.11.010) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Absolute numbers of CD19+ B cells (Left), percentages of CD19+CD21low B cells (Center), and percentages of CD4+CD45RA+ naive T cells (Right) significantly distinguish patients with first diagnosis of chronic graft-versus-host disease (cGVHD cohort) from those never experiencing chronic graft-versus-host disease (No cGVHD cohort). Data are shown in box plots. ● represents outliers. Biology of Blood and Marrow Transplantation 2015 21, 250-258DOI: (10.1016/j.bbmt.2014.11.010) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Receiver operating characteristic (ROC) curves for CD3−CD56+/CD3−CD56high NK cells, CD3+/CD4+ T cells, CD4+CD45RA+/CD4+CD45RA+CD31+ T cells, BAFF/CD19+/CD19+CD21low B cells. ROC curves of the composite parameters are shown. indicates the reference line. Biology of Blood and Marrow Transplantation 2015 21, 250-258DOI: (10.1016/j.bbmt.2014.11.010) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions