New devices for asthma Journal of Allergy and Clinical Immunology

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Presentation transcript:

New devices for asthma Journal of Allergy and Clinical Immunology Donald P. Tashkin, MD Journal of Allergy and Clinical Immunology Volume 101, Issue 2, Pages S409-S416 (February 1998) DOI: 10.1016/S0091-6749(98)70233-7 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Effect of nebulizer brand on respirable mass output of nebulizer (closed bars) and respirable mass available to patient (open bars). Adapted with permission from Hess D, Fisher D, Williams P, Pooler S, Kacmarek RM. Chest 1996;110:498-505. Journal of Allergy and Clinical Immunology 1998 101, S409-S416DOI: (10.1016/S0091-6749(98)70233-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Breakdown of CFCs by solar radiation releases active chlorine fragments that destroy ozone. Adapted with permission from Hayman G. Br J Clin Pract 1995;79:2-6. Journal of Allergy and Clinical Immunology 1998 101, S409-S416DOI: (10.1016/S0091-6749(98)70233-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Cumulative dose response of salbutamol sulfate in CFC-free system versus CFC-salbutamol in patients with asthma (n = 24). Mean (± SE) change from predose FEV1. Airomir, salbutamol sulfate in CFC-free system. Adapted with permission from Tashkin D. Br J Clin Pract 1995;79:33-4. Journal of Allergy and Clinical Immunology 1998 101, S409-S416DOI: (10.1016/S0091-6749(98)70233-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Cumulative dose response of salbutamol sulfate in CFC-free system versus CRC-salbutamol in patients with asthma (n = 24). Mean (± SE) change from predose heart rate. Airomir, salbutamol sulfate in CFC-free system. Predose heart rate for salbutamol sulfate in CFC-free system patients was 76.0 ± 9.0 beats/min and for CFC-salbutamol patients was 74.4 ± 8.7 beats/min. Adapted with permission from Tashkin D. Br J Clin Pract 1995;79:33-4. Journal of Allergy and Clinical Immunology 1998 101, S409-S416DOI: (10.1016/S0091-6749(98)70233-7) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Effect of multiple MDI actuations into spacer on amount of drug available per puff. Adapted with permission from O'Callaghan C, Lynch J, Cant M, Robertson C. Thorax 1993;48:603-6. Journal of Allergy and Clinical Immunology 1998 101, S409-S416DOI: (10.1016/S0091-6749(98)70233-7) Copyright © 1998 Mosby, Inc. Terms and Conditions