Metabolic profiling of livers and blood from obese Zucker rats Natalie J. Serkova, Matthew Jackman, Jaimi L. Brown, Tao Liu, Ryutaro Hirose, John P. Roberts, Jacquelyn J. Maher, Claus U. Niemann  Journal of Hepatology  Volume 44, Issue 5, Pages 956-962 (May 2006) DOI: 10.1016/j.jhep.2005.07.009 Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 1 (A) and (B): Representative histology from a lean Zucker rat at magnification 100× (A) and magnification 200× (B). Liver parenchyma shows normal structure. (C) and (D): Representative histology from an obese Zucker rat at magnification 100× (C) and magnification 200× (D). Slide A: no significant fatty changes are present. Slide C: rare hepatocytes show large droplet fat. Significant steatotic changes (>30% fatty infiltration) were not present on either slide. [This figure appears in colour on the web.] Journal of Hepatology 2006 44, 956-962DOI: (10.1016/j.jhep.2005.07.009) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Representative 1H-NMR spectra from water-soluble acid extracts of livers from lean (A) and obese (B) Zucker rats. 1, glutamate; 2, glutamine; 3, glutathione; Ala, alanine; OH-But, hydroxybutyrate; Glc, glucose; Glyc, glycogen; Lac, lactate; Suc, succinate; Val, valine+leucine+isoleucine. Journal of Hepatology 2006 44, 956-962DOI: (10.1016/j.jhep.2005.07.009) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Methionine metabolism in the liver. 1, methionine adenosyltransferase; 2, vitamin B6; DMG, dimethylglycine; GSH, glutathione; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine. [This figure appears in colour on the web.] Journal of Hepatology 2006 44, 956-962DOI: (10.1016/j.jhep.2005.07.009) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions