The Impact of Combined Use of Opioids, Antipsychotics, and Anxiolytics on Survival in the Hospice Setting  Marin Golčić, MD, Renata Dobrila-Dintinjana, PhD, MD, Goran Golčić, PhD, MD, Aleksandar Čubranić, PhD, MD  Journal of Pain and Symptom Management  Volume 55, Issue 1, Pages 22-30 (January 2018) DOI: 10.1016/j.jpainsymman.2017.08.004 Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 1 Kaplan-Meier curves comparing the uses of antipsychotics, anxiolytics, and different opioid doses on survival (time shown as days). Log-rank test showed significance (P < 0.05) for opioid doses over 300 mg OME/day as well as the use of only one type of antipsychotic and anxiolytic. OME = oral morphine equivalent. Journal of Pain and Symptom Management 2018 55, 22-30DOI: (10.1016/j.jpainsymman.2017.08.004) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 2 Kaplan-Meier curve comparing survival between four groups of patients with different combination of antipsychotics, anxiolytics, and opioids. Log-rank test showed significantly longer survival in ANX and/or APS (P = 0.025) and OPI + ANX + APS groups (P = 0.002) compared with group of patients with no such medications. A trend toward longer survival was present in all combinations (graph not shown). ANX = anxiolytics; APS = antipsychotics; OPI = opioids. Journal of Pain and Symptom Management 2018 55, 22-30DOI: (10.1016/j.jpainsymman.2017.08.004) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 3 Categorized histogram exhibiting number of observed deaths per day of the week. Journal of Pain and Symptom Management 2018 55, 22-30DOI: (10.1016/j.jpainsymman.2017.08.004) Copyright © 2017 American Academy of Hospice and Palliative Medicine Terms and Conditions