Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for.

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Presentation transcript:

Outcome and Biomarker Analysis from a Multicenter Phase 2 Study of Ipilimumab in Combination with Carboplatin and Etoposide as First-Line Therapy for Extensive-Stage SCLC Edurne Arriola, MD, PhD, Matthew Wheater, FRCP, Ian Galea, PhD, Nadia Cross, B.Med.Sci, Tom Maishman, MSc, Debbie Hamid, BAPPA, Louise Stanton, MSc, Judith Cave, FRCP, Tom Geldart, BSc, M.B.B.S., FRCP, DM, Clive Mulatero, MB, Vannessa Potter, PhD, Sarah Danson, PhD, Pennella J. Woll, FRCP, Richard Griffiths, FRCP, Luke Nolan, PhD, Christian Ottensmeier, MD, PhD Journal of Thoracic Oncology Volume 11, Issue 9, Pages 1511-1521 (September 2016) DOI: 10.1016/j.jtho.2016.05.028 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 CONSORT diagram showing the disposition of patients in the ICE (ipilimumab, carboplatin, and etoposide) study. ITT, intention to treat. Journal of Thoracic Oncology 2016 11, 1511-1521DOI: (10.1016/j.jtho.2016.05.028) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Kaplan-Meier plots for progression-free survival (PFS) according to the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.0, (A) and immune-related response criteria (B) and according to autoantibody status at baseline (C). CI, confidence interval; irRC, immune-related response criteria; NR, not reached. Journal of Thoracic Oncology 2016 11, 1511-1521DOI: (10.1016/j.jtho.2016.05.028) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Kaplan-Meier plots for overall survival (A) and according to autoantibody status at baseline (B). OS, overall survival; CI, confidence interval. Journal of Thoracic Oncology 2016 11, 1511-1521DOI: (10.1016/j.jtho.2016.05.028) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Supplementary Figure 1 Journal of Thoracic Oncology 2016 11, 1511-1521DOI: (10.1016/j.jtho.2016.05.028) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Supplementary Figure 2 Journal of Thoracic Oncology 2016 11, 1511-1521DOI: (10.1016/j.jtho.2016.05.028) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions