Testing of a new pneumatic device to cause pain in humans

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Presentation transcript:

Testing of a new pneumatic device to cause pain in humans Schubert H.M. , Lorenz I.H. , Zschiegner F , Kremser C , Hohlrieder M , Biebl M , Kolbitsch C , Moser P.L. British Journal of Anaesthesia Volume 92, Issue 4, Pages 532-535 (April 2004) DOI: 10.1093/bja/aeh097 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 The device fixed to the anterior margin of the tibia that is sensitive to pressure pain. The detail shows the inner surface of the pressure device with the thumper (indicated by an arrow). British Journal of Anaesthesia 2004 92, 532-535DOI: (10.1093/bja/aeh097) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Pain tolerance (%MPE) during remifentanil infusion (0.025, 0.05, 0.075, and 0.1 μg kg−1 min−1). The regression line (broken line) is given by the equation y=–1.81x2+32.4x –29.78 (R=0.975). The 50% MPE was found at 0.05 μg kg−1 min−1. *Indicates significance (P<0.05) to pre (pre) and postdrug (post) control. British Journal of Anaesthesia 2004 92, 532-535DOI: (10.1093/bja/aeh097) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Logarithm dose vs effect relationship for remifentanil infusion. British Journal of Anaesthesia 2004 92, 532-535DOI: (10.1093/bja/aeh097) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions