Nuclear Pores Set the Speed Limit for Mitosis Abigail Buchwalter, Martin W. Hetzer  Cell  Volume 156, Issue 5, Pages 868-869 (February 2014) DOI: 10.1016/j.cell.2014.02.004 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Nuclear Pores Impact the Spindle Assembly Checkpoint (Left) The Mad1-Mad2 complex is anchored to the NPC via Tpr in interphase, where it catalyzes the activation of O-Mad2 to C-Mad2 as it traffics through the nuclear pore. Activated C-Mad2 then accumulates in APC/C inhibitory MCCs in the cytosol. (Right) The Mad1-Mad2 complex is anchored to unoccupied kinetochores during mitosis, generating more MCCs and preventing the metaphase-to-anaphase transition until all chromosomes are bioriented on the spindle. NPC, nuclear pore complex; NE, nuclear envelope; MCC, mitotic checkpoint complex. Cell 2014 156, 868-869DOI: (10.1016/j.cell.2014.02.004) Copyright © 2014 Elsevier Inc. Terms and Conditions