Munir Boodhwani, MD, William E

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Presentation transcript:

Safety and Efficacy of a Novel Gel for Vascular Occlusion in Off-Pump Surgery Munir Boodhwani, MD, William E. Cohn, MD, Jun Feng, MDPhD, Basel Ramlawi, MD, Shigetoshi Mieno, MD, Alexander Schwarz, PhD, Frank W. Sellke, MD The Annals of Thoracic Surgery Volume 80, Issue 6, Pages 2333-2337 (December 2005) DOI: 10.1016/j.athoracsur.2005.05.031 Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Duration of left anterior descending coronary artery (LAD) ischemia increased with increasing amounts of injected gel (Spearman r = 0.64; p = 0.02). (• = occlusion time for varying quantities of gel.) The Annals of Thoracic Surgery 2005 80, 2333-2337DOI: (10.1016/j.athoracsur.2005.05.031) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Left anterior descending coronary artery (LAD) flow. Coronary flow patterns during LAD reperfusion were similar in treatment and control groups (p = 0.51). (BL = baseline; max = maximum flow.) The Annals of Thoracic Surgery 2005 80, 2333-2337DOI: (10.1016/j.athoracsur.2005.05.031) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Regional wall motion. Regional myocardial function, as measured by percentage of segmental shortening normalized to baseline during ischemia and reperfusion, which was similar in treatment and control groups (p = 0.89). (BL = baseline; I = ischemia, Rep = reperfusion.) The Annals of Thoracic Surgery 2005 80, 2333-2337DOI: (10.1016/j.athoracsur.2005.05.031) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Microvessel reactivity was similar between treatment (dashed lines) and control (solid lines) groups in both (A) ischemic (LAD) and (B) non-ischemic (circumflex) territories to endothelium-dependent vasodilator, ADP, and endothelium independent vasodilator, SNP. Microvessel relaxation in response to endothelium-dependent vasodilator, substance P, was mildly impaired in treatment versus control groups in both ischemic and nonischemic regions (p < 0.01). (ADP = adenosine diphosphate; LAD = left anterior descending coronary artery; SNP = sodium nitroprusside.) The Annals of Thoracic Surgery 2005 80, 2333-2337DOI: (10.1016/j.athoracsur.2005.05.031) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions