Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas

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Presentation transcript:

Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas Yago Nieto, Benigno C. Valdez, Peter F. Thall, Sairah Ahmed, Roy B. Jones, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Muzaffar Qazilbash, Alison Gulbis, Paolo Anderlini, Amin Alousi, Nina Shah, Qaiser Bashir, Yan Liu, Yasuhiro Oki, Frederick Hagemeister, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Richard Champlin, Borje S. Andersson Biology of Blood and Marrow Transplantation Volume 21, Issue 11, Pages 1914-1920 (November 2015) DOI: 10.1016/j.bbmt.2015.06.003 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Event-free (EFS) and overall survival (OS) curves. (A) DLCL subgroup (n = 52). (B) HL subgroup (n = 20). Biology of Blood and Marrow Transplantation 2015 21, 1914-1920DOI: (10.1016/j.bbmt.2015.06.003) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Event-free survival according to PET status at transplantation. (A) DLCL subgroup. (B) HL subgroup. Biology of Blood and Marrow Transplantation 2015 21, 1914-1920DOI: (10.1016/j.bbmt.2015.06.003) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Representative cases of decrease in the level of PARP-1 in patients treated with Bu/Mel (A), Gem/Bu/Mel (B), and vorinostat/Gem/Bu/Mel (C). Biology of Blood and Marrow Transplantation 2015 21, 1914-1920DOI: (10.1016/j.bbmt.2015.06.003) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions